Abstract
Objectives: The study was designed to assess lipid peroxidation and oxidative defense system in patients with breast cancer, following them from the time of diagnosis through surgery and treatment. .
Patients and Methods: The study was conducted in Al-Jammhori Hospital, Mosul, Iraq. Twenty three women with breast cancer types III and IV and 22 apparently healthy women as a control group were included in this study. Blood samples (5 ml) were taken from patients and controls and analysed for serum malondialdehyde (MDA) and total antioxidant status (TAS) concentration. Blood samples were taken from patients one week before and after the operation and other blood samples were taken two weeks after the first dose of infusion with a combination therapy of cyclophosphamide, 5-fluorouracil and doxorubicin. The therapy was started two weeks after the surgery every 6 weeks for 6 cycles.
Results: In breast cancer women, serum MDA was significantly higher (P
