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-A pharmacy and Medicine Journal published by the college of pharmacy , University of Mosul. -Date of first issue(2001). -No. of issue per year (1). -No. of papers per issue. -No. of issue published between 2001-2011(11)issue.
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Journal Information

Publisher: Mosul University

Email:  iraqi.journal.pharmacy@gmail.com

Editor-in-chief: Ass. Prof. Dr. Zeina Abdul mnium Abdul majeed

Print ISSN: 1680-2594

Online ISSN: 2264-2522

Antidiabetic Prescription and Glycemic Control in Patients With Type 2 Diabetes Mellitus

Isam Mahmood; Raghad Othman Aldabbagh

Iraqi Journal of Pharmacy, Volume 15, Issue 1, Pages 1-11
DOI: 10.33899/iphr.2018.164166

Objective: To detertmine the antidiabetic  treatment among individuals with type 2 diabetic  patients in Mosul city,  the number of patients who attained the glycemic target (good glycemic control) and patients who failed to attained glycemic target (poor glycemic control) and to investigate factors that may be associated with poor glycemic control.
Patients and Methods: 299 patients with type 2 diabetes mellitus of both sexes were participated in this study. The patients were divided into 2 groups according to the values of HbA1C: Group 1 (good glycemic control) and  group 2 (poor glycemic control). A questionnaire form was prepared to record detailed informations about each patient such as age, drugs used, education level, diabetic family history, adherence to treatment, exercise, and diet. HbA1c level was analyzed using high performance liquid chromatography. Other parameters including total cholesterol, high density lipoprotein-cholesterol (HDL), triglycerides, low density lipoprotein-cholesterol (LDL) and serum glucose concentration were measured using special kits.
Results: The antidiabetic drugs used including metformin, glibenclamide and glimepiride, used alone and in combinations including metformin plus glibenclamide and metformin plus insulin. Fifty patients (16.7%) have good glycemic control and 249 patients (83.3%) have poor glycemic control. Comparison between number of poor glycemic control of metformin and glibenclamide showed non significant difference. Comparison between poor glycemic control of metformin plus glibenclamide and metformin plus insulin showed highly significant difference. Comparison between mono-therapy and combination therapy showed highly significant difference. High proportions of poor glycemic control were obtained with ages >40 males, overweight and obese, low educational level, family history of diabetes, use of herbs, long duration of the disease, low HDL-cholesterol, high atherogenic index, non adherence to treatment, diet and exercise.
Conclusion: This study showed that high proportions of type 2 diabetic patients were on combination therapy and the high proportions of the patients were poor glycemic control. Many factors were found to be associated with poor glycemic control including age >40 males, overweight and obesity, low educational level, family history of diabetes, use of herbs, long duration of the disease, non adherence to treatment, diet, and exercise.

Histological and Histochemical Changes Induced by Human Chorionic Gonadotropin on Prostate of Adult albino Rats

Waleed H. Kasim; Maha A. Al-Sammak

Iraqi Journal of Pharmacy, Volume 15, Issue 1, Pages 12-21
DOI: 10.33899/iphr.2018.164167

Aims of the study: To evaluate the histological and histochemical changes induced by human chorionic gonadotropin (hCG) on the adult prostate and to correlate the changes with the levels of testosterone.
Materials and Methods: eighty adult male albino rats were divided into 4 groups; 3 treated and 1 control. The treated groups were received 10, 50 or 100 IU/kg BW of hCG, while the controls received normal saline. The doses were given twice weekly for 3 months via subcutaneous injections. Subsequently, on day 1, 30, 60 and 90 post therapy, blood samples and the prostate glands were obtained for evaluation.
Results: All the doses of hCG caused accumulation of secretory products within the prostate, which resulted in dilatation of the acinar lumens, reduction of the mucosal folds, and non dose dependent diminution in height of the lining epithelial cells. Moreover, foci of hyperplasic cells were observed in the prostate. The therapy increased the collagen fibers of the gland. The general distribution of the Periodic Acid-Sciff (PAS) +ve material was not altered. Most of these changes were reversible within 3 months.
Conclusions: Treatment with hCG causes accumulation of secretory products within the prostate and in turn affects the structure of the prostate.
 

Effects of Human Chorionic Gonadotropin on the Testis of Adult Albino Rats: A Histological and Histochemical Study

Waleed H. Kasim; Maha A. Al-Sammak

Iraqi Journal of Pharmacy, Volume 15, Issue 1, Pages 22-36
DOI: 10.33899/iphr.2018.164168

Aims of the study: To evaluate the histopathological changes induced by human chorionic gonadotropin (hCG) on the adult testis and to correlate the changes with the levels of testosterone, LH and FSH, as well as to assess their reversibility.
Methods: 80 adult male albino rats were divided into 4 groups; 3 treated and 1 control. The treated groups were received 10, 50 or 100 IU/kg BW of hCG, while the controls received normal saline. The doses were given twice weekly for 3 months via S.C. injections. Subsequently, on day 1, 30, 60 and 90 post therapy, blood samples and the testes were obtained for evaluation.
Results: Low dose of hCG caused increase in number of germ and Sertoli cells. Contrary, higher doses decreased their population, and resulted in exfoliation of the germ cells. Furthermore, reduction in the thickness of the tubular basement membrane, congestion of the inter-tubular blood vessels and interstitial bleeding were observed in the higher dose groups. All the doses caused interstitial oedema, hyperplasia and hypertrophy of Leydig cells, as well as diminution in the collagen fibers. All these changes were reversible within 3 months.
Conclusions: Only the low doses of hCG stimulate the spermatogenesis, whereas higher doses suppress sperm production.
 

Fluorine important element in new drugs synthesis: Review Study

Ahmed A. Mahmood; Mohammed A. Al-Iraqi; Faris T. Abachi

Iraqi Journal of Pharmacy, Volume 15, Issue 1, Pages 37-45
DOI: 10.33899/iphr.2018.164169

Objective:To evaluate the role of fluorine atom in modern drug synthesis.
Methods:  Different types of fluorinated were prepared, antimicrobials, antivirals, F-NSAIDs, peptides and protein synthesis.
Results: Recent developments and future prospects of fluorine in medicinal chemistry and chemical biology. The extraordinary potential of fluorine - containing biologically relevant molecules in antimicrobial or antivirial agents, or  peptide or protein chemistry, medicinal chemistry, chemical biology, pharmacology, and drug discovery as well as diagnostic and therapeutic applications, was recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of fluorine chemistry has been rapidly expanding its biomedical frontiers.
Conclusion: This review how to list of fluorinated drugs( Antimicrobial agents , anticancer agents, Antiviral agents, and study their  physicochemical properties of fluorine drugs.
 

Anti-adhesion therapy, a promising alternative in the infections treatment

Waleed Khalid Madle; Mohammed Abdullah Ajeel; Muhammad A. Alkataan; Akram Abdullah Ajeel; Wijdan I.A. Abd-alwahab

Iraqi Journal of Pharmacy, Volume 15, Issue 1, Pages 46-60
DOI: 10.33899/iphr.2018.164196

Objective: Antibiotic resistance (AR) represents one of the most important health problems worldwide due to the fact that it significantly lowers the number of effective antibacterial agents. Many mechanisms were studied to reduce emerge of AR, one of these is the use of Anti-adhesion Methods: keywords were used to search Most of the subject available articles. Following that, a grammatical examination was done for the vocabulary associated with the literature review. Results: Anti-adhesion agents represent vital approach to stop or treat bacterial infections. As these agents focus on bacterial virulence and pathogenicity properties (e.g. adhesion and colonization).These agents considered a perfect alternative for an antibiotic, with the infectious process inhibiting advantage in the first step to reduce the damage. These agents inhibit bacteria attachment to the surface of the host cell through interfering with the assembly of host receptor, bacteria-host cell assembly or adhesion biosynthesis. Bacterial adhesions antibodies can prevent surface epitopes required for bacteria-host cell attachment by the application of anti-adhesion strategy to decrease AR or reduce the need for the effective antibiotic doses .
Conclusions: Anti-adhesion therapy includes efforts for preventing adherence, reduces virulence, and biofilm formation. These have advantages over classical antibiotics through blocking pathogenicity without destroying bacteria and it also have a synergistic effect when applied with antibiotics

Synergistic activity of azithromycin combined with metronidazole against toxoplasmosis in experimental mice

Ziad H.Al-jader; Abdulsalam M. Al-Mukhtar

Iraqi Journal of Pharmacy, Volume 9, Issue 1, Pages 32-35
DOI: 10.33899/iphr.2010.49981

Objective: To evaluate the efficacy of synergistic activity of azithromycin combined with metronidazole against toxoplasmosis experimentally induced in murine model.
Material & Methods: Albino mice model (balb/c mice) acutly infected with tachyzoites, were treated for 10days from day +1 postinfection with administration of azithromycin combined with metronidazol.
Results: The results showed that prolonged survival of albino mice relative to that of untreated control, and the dead mice were found only in the control group. This experiment showed that a remarkable synergistic effect on toxoplasmosis was obsereved when azithromycin was adminstratered in combination with metronidazole at cuurative dosage i.e.(250 and 200 mg/kg/day), respectively. These results showed that azithromycin, which is remarkably active on toxoplasmosis, significantly potentiates the curative effect of metronidazol in the treatment. The treated mice in uncontrolled group were completely cured from toxoplasmosis as their brain were free of T. gondii cyst either microscopically or by bioassay.
Conclusion: Combined drugs of azithromycin and metronidazole showed a cure rate of 100% in experimental murine toxoplasmosis.

The effect of antioxidant supplementation in the treatment of epilepsy

Nazar A.K. hamid

Iraqi Journal of Pharmacy, Volume 11, Issue 2, Pages 27-33
DOI: 10.33899/iphr.2011.49893

Aim: To assess serum level of malondialdehyde (MDA) and total antioxidant status
(TAS) as a representative of oxidative stress in patients with generalized epilepsy and
to evaluate the therapeutic effect of the antioxidant (vitamin E and vitamin C) on the
levels of MDA,TAS and frequency of seizures attacks after two months therapy. for a
period of two months as a supplementation therapy.
Subjects and Methods: The study was conducted in Iben-seena Hospital in Mosul
city-Iraq. Fifty three patients with generalized epilepsy were included in this study
(32 male and 21 female). The study included 40 apparently healthy subjects, age and
sex matched as a control group. Initially from both the patients and controls, blood
samples were taken. Another blood samples were taken from the patients 2 months
after vitamin E and vitamin C treatment, blood samples were analysed for serum
MDA and serum TAS.
Result: Serum MDA was found to be significantly higher ( P<0.001) and serum TSA
was significantly lower (P<0.001) in patients with generalized epilepsy prior vitamin
E and vitamin C supplementation in comparison to controls. After vitamin E and C
supplementation there was a significant reduction (P<0.001) in the serum MDA levels
with a significant increase (P<0.001) in the serum TAS. Also we found a reduction in
seizure frequency of greater than 70% after vitamin E and C supplementation.
Conclusion: a significant reduction of TSA was reported in patients with epilepsy.
Administration of vitamin E and C produced a significant reduction of serum MAD
levels and a significant elevation of serum TAS, associated with a reduction of greater
than 70% of seizure frequency. The study suggests the administration of vitamin E
and C as adjunct to antiepileptic drugs.

Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning

Ashwaq Najeem Eldeen; Mohammed Mahmood Mohammed; Mohammad Dakhel

Iraqi Journal of Pharmacy, Volume 9, Issue 1, Pages 16-20
DOI: 10.33899/iphr.2010.49979

Lead is a neurotoxic metallic element that can be absorbed by the body, primarily through the lungs and stomach. Generally, lead poisoning occurs slowly, resulting from the gradual accumulation of lead in bone and tissue after repeated exposure. Left untreated, lead poisoning can damage many internal organs, including the kidney and the nervous system. Recent studies have shown that lead causes oxidative stress by inducing the generation of reactive oxygen species and reducing the antioxidant defense system of cells. This suggests that antioxidants may play an important role in the treatment of lead poisoning as a kind of scavengers of free radicals.
Antioxidant is any substance that reduces oxidative damage such as that caused by free radicals. Free radicals are highly reactive chemicals that attack molecules by capturing electrons and thus modifying chemical structures. Melatonin, a powerful antioxidant, is a hormone produced naturally in the pineal gland at the base of the brain.
This study was designed to evaluate the clinical significance of melatonin in ameliorating the oxidative stress induced due to chronic exposure to lead.
Twenty male patients with chronic lead poisoning and their 20 aged matched normal controls with an age range 35-45 years were included in this study. Treatment included 3 mg capsule of melatonin antioxidant at night for two months. Heparinized venous blood samples were collected from patients before treatment and at one and two months after treatment as well as from controls to measure erythrocytes malondialdehyde (RMDA), plasma total antioxidant status (TAS), blood lead (Pb) and serum zinc (Zn) levels.
The results of the study showed a significant antioxidant activity of melatonin in eliminating the oxidative consequences of lead exposure revealed by significant reduction in oxidative stress markers ( RMDA and Pb) with a significant increase in body antioxidant defense mechanisms(TAS and Zn).

Evaluation of CA 15-3, Her-2/neu and estrogen/progesterone status in breast cancer patients treated by surgical removal and chemotherapy

Taha H Taha Al-siagh; Shahbaa A Al-bayati; Faris A Ahmed

Iraqi Journal of Pharmacy, Volume 12, Issue 1, Pages 1-7
DOI: 10.33899/iphr.2012.62338

Objective: This study was conducted to evaluate serum CA 15-3 in breast cancer patients after surgery and chemotherapy. The relationship between serum CA 15-3 and Her-2/neu, estrogen, or progesterone receptors were also studied in the breast cancer patients.
Patients and methods: This study was conducted at Al-Jammhori Teaching Hospital, and Al-Zahrawi Private Hospital, Mosul, Iraq, during the period from January to Jun 2011. Fifty breast cancer women diagnosed by using triple assessments by a surgeon (history examination, ultrasound mammography, and fine needle aspiration cytology) were included in the study. Blood samples (5 mL) were taken from the patients and analyzed for serum CA 15-3 by monoclonal antibody technique. The blood samples were taken from the patients a week before and after one week of the operation and other blood samples were taken after two weeks of the first cycle of chemotherapy treatment. Combination therapy of 5-fluorouracil, epirubicin, cyclophosphamide, for three cycles every 21 days, was given to the patients, followed by three cycles docytaxil every 21 days. Samples from the tumor on paraffin sections taken from the patients were analyzed for Her-2/neu, estrogen and progesterone receptors by immunochemical methods.
Results: Serum CA 15-3 was significantly decreased by 54% (p ≤ 0.001) after surgical removal of the cancer compared with results before surgery. Chemotherapy of the patients further decreased serum CA 15-3 significantly by 78% (p ≤ 0.001) compared with the results before surgery. CA 15-3 and tumor size in positive Her-2/neu patients were significantly higher than in negative Her-2/neu patients. However, serum CA 15-3 and tumor size in positive estrogen patients were significantly lower than in negative estrogen patients. In progesterone positive patient's serum CA 15-3 was only significantly (p ≤ 0.001) lower than in the negative progesterone patients. Mean ages was significantly (p ≤ 0.001) higher in positive Her-2/neu patients than in negative Her-2/neu patients. However, mean ages was significantly (p ≤ 0.001) higher in positive estrogen and progesterone patients than in negative receptors. Metastasis occurred in 39 patients (78 %) out of the studied patients. Negative significant correlation was noticed between Her 2/neu and estrogen receptors (r= - 0.745, p ≤ 0.001). Negative significant correlation was also noticed between Her 2/neu and progesterone receptors (r= - 0.786, p ≤ 0.001). Weak but significant correlation was found between serum CA 15-3 and tumor size (r= 0.281, p≤ 0.05).
Conclusion: CA 15-3 and Her 2/neu are useful tumor markers for diagnosis of breast cancer in the treatment through surgery and chemotherapy. The co-expression between hormonal and Her-2/neu receptors is negative. The need for more sensitive tumor markers is still wanted.

Serum magnesium in diabetic retinopathy: relation to glycated haemoglobin and lipid profile

Amjad H. Al- Naemi

Iraqi Journal of Pharmacy, Volume 7, Issue 1, Pages 57-67
DOI: 10.33899/iphr.2008.50097

The aim of this study was to evaluate serum magnesium status in diabetic retinopathy and to investigate its relation to serum lipid profile and glycated haemoglobin (HbA1c) as a marker for long- term metabolic control in diabetes. The current case control study has enrolled 25 type 2 diabetics without retinopathy (Group 1), 25 diabetics with retinopathy (Group 2) and 21 apparently healthy non- diabetic control subjects (Group 3). Overnight fasting serum magnesium, lipid profile and HbA1c concentration were analyzed for all subjects. The mean serum magnesium level was significantly lower in Group (2) compared to that of Group 1 (p< 0.001). The mean serum triglycerides (TGs) and HbA1c levels were significantly higher in Group 2 (p< 0.0001). No statistically significant differences were noticed comparing the mean serum total cholesterol (TC) and LDL-cholesterol concentrations in both groups 1 and 2 (p> 0.05).
The study revealed a significant negative correlation between serum magnesium on one hand and serum TGs, TC, LDL- cholesterol and HbA1c on the other hand where r= - 0.646, - 0.47, - 0.335, and - 0.825 respectively. Meanwhile serum magnesium was significantly and positively correlated with HDL- cholesterol levels (r= 0.395, p> 0.001). Using Forward Stepwise Multiple Regression analysis, the study revealed that hypomagnesaemia, poor glycaemic control and increasing duration of diabetes are the most important contributors to the cumulative risk for the development of diabetic retinopathy (Odds ratios 16.65, 566 and 7.36 respectively).
In conclusion, magnesium depletion is a significant risk factor for, and a frequent finding in, diabetic retinopathy beside poor glycaemic control, dyslipidaemia (mainly hypertriglyceridaemia), and increasing duration of uncontrolled diabetes. The significant association between hypomagnesaemia and high fasting serum levels of TGs, TC, LDL-cholesterol and HbA1c would rather support the suggested role for magnesium depletion in the metabolic derangements associated with retinopathy in diabetic patients. Further studies on the effects of magnesium supplementation for diabetic patients are necessary to investigate the spectrum of metabolic improvements following magnesium therapy and the degree to which the risk of diabetic retinopathy might be reduced.

Evaluation of CA 15-3, Her-2/neu and estrogen/progesterone status in breast cancer patients treated by surgical removal and chemotherapy

Taha H Taha Al-siagh; Shahbaa A Al-bayati; Faris A Ahmed

Iraqi Journal of Pharmacy, Volume 12, Issue 1, Pages 1-7
DOI: 10.33899/iphr.2012.62338

Objective: This study was conducted to evaluate serum CA 15-3 in breast cancer patients after surgery and chemotherapy. The relationship between serum CA 15-3 and Her-2/neu, estrogen, or progesterone receptors were also studied in the breast cancer patients.
Patients and methods: This study was conducted at Al-Jammhori Teaching Hospital, and Al-Zahrawi Private Hospital, Mosul, Iraq, during the period from January to Jun 2011. Fifty breast cancer women diagnosed by using triple assessments by a surgeon (history examination, ultrasound mammography, and fine needle aspiration cytology) were included in the study. Blood samples (5 mL) were taken from the patients and analyzed for serum CA 15-3 by monoclonal antibody technique. The blood samples were taken from the patients a week before and after one week of the operation and other blood samples were taken after two weeks of the first cycle of chemotherapy treatment. Combination therapy of 5-fluorouracil, epirubicin, cyclophosphamide, for three cycles every 21 days, was given to the patients, followed by three cycles docytaxil every 21 days. Samples from the tumor on paraffin sections taken from the patients were analyzed for Her-2/neu, estrogen and progesterone receptors by immunochemical methods.
Results: Serum CA 15-3 was significantly decreased by 54% (p ≤ 0.001) after surgical removal of the cancer compared with results before surgery. Chemotherapy of the patients further decreased serum CA 15-3 significantly by 78% (p ≤ 0.001) compared with the results before surgery. CA 15-3 and tumor size in positive Her-2/neu patients were significantly higher than in negative Her-2/neu patients. However, serum CA 15-3 and tumor size in positive estrogen patients were significantly lower than in negative estrogen patients. In progesterone positive patient's serum CA 15-3 was only significantly (p ≤ 0.001) lower than in the negative progesterone patients. Mean ages was significantly (p ≤ 0.001) higher in positive Her-2/neu patients than in negative Her-2/neu patients. However, mean ages was significantly (p ≤ 0.001) higher in positive estrogen and progesterone patients than in negative receptors. Metastasis occurred in 39 patients (78 %) out of the studied patients. Negative significant correlation was noticed between Her 2/neu and estrogen receptors (r= - 0.745, p ≤ 0.001). Negative significant correlation was also noticed between Her 2/neu and progesterone receptors (r= - 0.786, p ≤ 0.001). Weak but significant correlation was found between serum CA 15-3 and tumor size (r= 0.281, p≤ 0.05).
Conclusion: CA 15-3 and Her 2/neu are useful tumor markers for diagnosis of breast cancer in the treatment through surgery and chemotherapy. The co-expression between hormonal and Her-2/neu receptors is negative. The need for more sensitive tumor markers is still wanted.

Unlicensed and off-label drug use in paediatric wards

Suhair Moayid Rasheed

Iraqi Journal of Pharmacy, Volume 9, Issue 1, Pages 53-57
DOI: 10.33899/iphr.2010.50063

Objective: To determine the proportion of unlicensed &/or off-label prescriptions in paediatric
patients.
Patients & Methods; This prospective study of drugs administered to children in two
paediatric hospital (ib-A!theer, A!-Kanasaa hospital for pediatrics in mosul city, over 6 months
from 1st Nov. 2007 to 1st May 2008. One hundred-forty children were included in this study
aged from at birth to 6 years admitted to paediatric medical wards. Drug-licensing status of all
prescriptions given to these patients was determined.
Results: Of the 1208 prescription given to these children, more than half of all prescriptions
626 (51 ,8%) were unlicensed or off-label. Where as 582 (48.2%) licensed. The most common
category of off-label use 365 (30.2%) was related to age 217 (17.9%), the other off-label uses
were related to dose and frequency of administration 77 (6.4%), indication 55 (4.6%) and
route of administration 16 (1.3%) and the most common reason of unlicensed preparation
was the administration of preparation not licensed for use at all.
Conclusion: The use of unlicensed or off- label medicines to treat children was found to be
common in paediatric patients, this problem is Widespread in peadiatric wards &the clinical

Synergistic activity of azithromycin combined with metronidazole against toxoplasmosis in experimental mice

Ziad H.Al-jader; Abdulsalam M. Al-Mukhtar

Iraqi Journal of Pharmacy, Volume 9, Issue 1, Pages 32-35
DOI: 10.33899/iphr.2010.49981

Objective: To evaluate the efficacy of synergistic activity of azithromycin combined with metronidazole against toxoplasmosis experimentally induced in murine model.
Material & Methods: Albino mice model (balb/c mice) acutly infected with tachyzoites, were treated for 10days from day +1 postinfection with administration of azithromycin combined with metronidazol.
Results: The results showed that prolonged survival of albino mice relative to that of untreated control, and the dead mice were found only in the control group. This experiment showed that a remarkable synergistic effect on toxoplasmosis was obsereved when azithromycin was adminstratered in combination with metronidazole at cuurative dosage i.e.(250 and 200 mg/kg/day), respectively. These results showed that azithromycin, which is remarkably active on toxoplasmosis, significantly potentiates the curative effect of metronidazol in the treatment. The treated mice in uncontrolled group were completely cured from toxoplasmosis as their brain were free of T. gondii cyst either microscopically or by bioassay.
Conclusion: Combined drugs of azithromycin and metronidazole showed a cure rate of 100% in experimental murine toxoplasmosis.

Comparative evaluation of different marketed products of ciprofloxacin tablets in vitro

Mus; ab M. Khalaf; Hiyam A Al-Taii; Imad A-J Thanoon

Iraqi Journal of Pharmacy, Volume 9, Issue 1, Pages 9-15
DOI: 10.33899/iphr.2010.49978

The contents of four ciprofloxacin tablets products available in the private pharmacies of Mosul city were measured according to the British Pharmacopoeia (BP). Some biopharmaceutical parameters such as content uniformity, disintegration, and hardness were also measured for the same products. In addition, the antibacterial activity of these four products were assessed by microbiological assay on different types of gram negative bacteria in vitro.
The results indicated that there is a little differences in the content uniformity of these products and they are within acceptable requirement of BP and United State Pharmacopoeia (USP). In the same manner, the weight variation, disintegration, and hardness were within acceptable range according to the BP and USP. The microbiological assay indicated that these different products produce approximately the same inhibition zones on the same bacterial type.
The above results may be useful to predict the bioavailability of these different products .

Screening of developmental dysplasia of the hip in the newborns

Mohamad Ah. Jasim; Bashar Sh. Mustafa

Iraqi Journal of Pharmacy, Volume 11, Issue 1, Pages 79-91
DOI: 10.33899/iphr.2011.49597

Background: Newborn babies are known to have risk for occurrence developmental
dysplasia of the hip so early clinical screening test is very important to detect this
problem and prevent further abnormal growth. The aim of this study is to find the rate
of occurrence of developmental dysplasia of the hip (DDH) among newborn babies
and establish good screening program.
Patients and methods: From August ٢٠٠٦ to March ٢٠٠٩ in AL-Khansaa
Maternity and Children Teaching hospitals, ٩٥٩٢ newborn babies were examined
clinically using Barlows and ortolani tests for detecting DDH.
Results: Only ١٦٢ newborn babies out of ٩٥٩٢ examined babies had DDH and it was
found more common among female and more on left side than right side. Female sex,
rural residence, first born baby breach, caesarean section positive family history,
multiple pregnancy post-mature babies, high birth weight (>٣٥٠٠ g).
Conclusion: The occurrence of neonatal DDH is still form a major problem among
newborn babies causing a lot of morbidity need to follow up to avoid further
complicating problem.

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