Pharmaceutical Chemistry
Synthesis and Pharmacological Profiles of 6,7-Dihydroxycoumarin and Its Derivatives: A Concise Review

Nameer Mazin Zeki; Yasser Fakri Mustafa

Volume 20, Supplementary Issue 1 , December 2023, Page 174-188

https://doi.org/10.33899/iphr.2023.143017.1059

Abstract
  Background: Esculetin, scientifically referred to as 6,7-dihydroxycoumarin, functions as the primary bioactive constituent found in Cortex Fraxini (commonly known as ash bark), an ancient Asian medicinal substance. Herbal practitioners utilize the outer layer of the branch or stem bark of Cortex Fraxini ...  Read More ...

Pharmacology and Toxicology
Statin Gastroprotective Mechanisms Independent of Gastric Acid Suppression

Dilgash A Abdullah; Hani Almukhtar

Volume 20, Supplementary Issue 1 , December 2023, Page 189-194

https://doi.org/10.33899/iphr.2023.142864.1056

Abstract
  Background: Statins have demonstrated various beneficial clinical outcomes, not only in patients with elevated cholesterol levels but also in those with normal levels, a collective phenomenon known as pleiotropic effects. In the cardiovascular system, statins exhibit numerous pleiotropic effects, including ...  Read More ...

Pharmacology and Toxicology
Mirabegron-Induced Smooth Muscle Relaxation: Review of the Suggested Mechanisms

Rahma Saadaldain Almallah; Hani Almukhtar

Volume 20, Supplementary Issue 1 , December 2023, Page 195-200

https://doi.org/10.33899/iphr.2023.142851.1057

Abstract
  Background: Mirabegron operates through a distinct mechanism compared to antimuscarinic agents. Its activation of β3-adrenoceptors results in the relaxation of the bladder during the filling phase of micturition. The activation of β3-adrenoceptors, which are connected to Gs-proteins, is hypothesized ...  Read More ...

Pharmacology and Toxicology
Systemic Adverse Effects of Topical Clobetasol and Counterfeit Cosmetic Products on Iraqi Women

Teeba H. Sagban; Ausama Ayob Jaccob; Abdulla Ayob Yaqoub; Huda Khadim

Volume 20, Supplementary Issue 1 , December 2023, Page 201-209

https://doi.org/10.33899/iphr.2023.143457.1061

Abstract
  Background: Topical corticosteroids (TCs) are widely used for dermatologic diseases. Unfortunately, there exists many adverse effects (local and systemic). These adverse effects are comparable to those observed when glucocorticoids are administered systemically, but they are typically less severe. Aim: ...  Read More ...

Pharmacology and Toxicology
The Effect of Cilnidipine on Insulin Sensitivity

Maha Abdalwahab Mahmood; Shatha Hani Mohammad

Volume 20, Supplementary Issue 1 , December 2023, Page 210-216

https://doi.org/10.33899/iphr.2023.143299.1060

Abstract
  Background: Cilnidipine, a common hypertension medication, is now being studied for its potential to improve insulin sensitivity, which plays a key role in regulating blood sugar levels. Recent research suggests that cilnidipine may benefit individuals with both hypertension and insulin resistance, offering ...  Read More ...

Pharmacognosy & Natural Products
Evaluation of Various In-vitro Biological Activities of Crude Quince Seed Ethanolic Extract

Raghad Riyadh Khalil

Volume 20, Supplementary Issue 1 , December 2023, Page 217-223

https://doi.org/10.33899/iphr.2023.144158.1063

Abstract
  Background: for a long time, natural bio-actives have been used to treat, cure, and prevent illnesses. Fruit seed crude extracts have been found to have various beneficial biological activities, such as anti-inflammatory, antioxidant, and antitumoral potential. Methods: this study investigated quince ...  Read More ...

Pharmacognosy & Natural Products
Exploring the Antimicrobial Activity of Quince Seeds Extracted by Two Different Methods

Eman Tareq Mohammed

Volume 20, Supplementary Issue 1 , December 2023, Page 224-235

https://doi.org/10.33899/iphr.2023.144159.1064

Abstract
  Background: The rise of resistance to numerous effective antimicrobic drugs and the necessity to investigate alternative agents to address this emerge are conspicuously underscored. Aim: The aim is to evaluate the TPC (total phenolic contents), TFC (total flavonoidal contents), and the antimicrobial ...  Read More ...

Pharmaceutical Chemistry
Thermosonication-Catalyzed Synthesis of New 3-Esterified Coumarins as Biocompatible Antitumor Candidates

Sawsan Hasan Hammodi

Volume 20, Supplementary Issue 1 , December 2023, Page 236-242

https://doi.org/10.33899/iphr.2023.144182.1066

Abstract
  Background: Coumarin chemical moiety and its-based molecules attracted a lot of research attention by chemists of natural products and organic synthesis. This attention works in two directions: synthetic approaches and biological activities. Methods: In this work, salicylaldehyde was condensed via a ...  Read More ...

Clinical biological Labs
Histological and Morphometric Effect of Amiodarone on the Ovary in Adult Female Albino Rats

Zahraa Abd-Alkader Tabou

Volume 20, Supplementary Issue 1 , December 2023, Page 243-249

https://doi.org/10.33899/iphr.2023.144294.1067

Abstract
  Background and objectives: Amiodarone is an antiarrhythmic medication used to treat abnormal heart rhythms. This study aimed to analyse the histological variations in ovarian follicles of rats after treatment with different doses of amiodarone and evaluate its effects on follicular growth parameters. ...  Read More ...

Pharmacology and Toxicology
Angiotensin-Converting Enzyme Inhibitors and Adipokines: The Role of Visfatin and Apelin in Cardiovascular Disease Management

Yaseen Khamees Jumaah; Zainab Haitham Fathi; Jehan Abdulwahab Mohammad

Volume 20, Supplementary Issue 1 , December 2023, Page 250-260

https://doi.org/10.33899/iphr.2023.143923.1062

Abstract
  Background: Angiotensin-converting enzyme (ACE) Inhibitors are medications pivotal in cardiovascular disease management, impacting the renin-angiotensin system which plays a critical role in cardiovascular health. These inhibitors not only modulate blood pressure and fluid balance but also influence ...  Read More ...