Quality of different brands of metronidazole available in jimma town, south west Ethiopia; A cross- sectional pharmaceutical quality study

Teshome Sosengo; Tesfaye Mohammed; Ramanjireddy Tatiparthi

Volume 17, Issue 1 , January 2020, Page 1-18

https://doi.org/10.33899/iphr.2020.167595

Abstract
  Background: WHO report of 2017 estimates that the rates of substandard and falsified medical products in low- and middle-income countries is approximately 10.5% with an estimated spend of US$ 30.5 billion.Objective: The purpose of the study is to assess the quality of different brands of metronidazole ...  Read More ...

Design, synthesis, and evaluation the anti-β-lactamase activity of new sulphathiazole-derived monobactam compounds

Ahmed A. J. Mahmood; Mohammed A. Al-Iraqi; Faris T. Abachi

Volume 17, Issue 1 , January 2020, Page 19-36

https://doi.org/10.33899/iphr.2020.167596

Abstract
  Objectives: β-Lactams are the most successful antibiotics for the management of infectious diseases. Unfortunately, the bacterial production of β-lactamase that hydrolyzes the β-lactam ring can inactivate these drugs. The use of β-lactamase inhibitors like (clavulanic acid) in combination ...  Read More ...

Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

Amina M. Al-Nima; Zahraa S. Qasim; Myasar Al-Kotaji

Volume 17, Issue 1 , January 2020, Page 37-56

https://doi.org/10.33899/iphr.2020.167597

Abstract
  Objectives: This work aims at formulating licorice as topical gel preparation and at exploring its antimicrobial efficacy against different types of microorganisms including two types of bacteria Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aerueginosa) and one type of yeast, Candida albicans ...  Read More ...

The Histologic Effect of Baclofen in Rat’s brain: An Experimental Study

Luma I. Al-Allaf; Wahda M. Al-Neaimy

Volume 17, Issue 1 , January 2020, Page 57-74

https://doi.org/10.33899/iphr.2020.167598

Abstract
  Background: Baclofen is the only clinically available metabotropic GABAB receptor agonist. Several reports has been discussed the efficacy of baclofen but the available data on its effect of the behavior and brains' histology are still limited.Objectives: This work aims to assess the effects of long ...  Read More ...

In-vitro Examination of The Potential Antibacterial Activity of Simvastatin

Hani Almukhtar; Hiyam A. Altaii; Musab M. Khalaf

Volume 17, Issue 1 , January 2020, Page 75-92

https://doi.org/10.33899/iphr.2020.167599

Abstract
  Background: Statins are group of medicines that block mevalonate pathway by competitive inhibition of the rate limiting enzyme hydroxy-methylglutaryl-CoA reductase (HMG-CoA). Statins additionally inhibit the biosynthesis of important isoprenoid intermediates which have a role in peptidoglycan synthesis ...  Read More ...

A review on the antibacterial potential of cantabiline-based derivatives

Noora T. Abdulaziz; Yasser F. Mustafa

Volume 17, Issue 1 , January 2020, Page 93-114

https://doi.org/10.33899/iphr.2020.167600

Abstract
  Objective: The target of this review study is to highlight the importance of cantabiline and its derived compound as antibacterial agents. Also, to take into consideration the characteristic structural features that can enhance the capability of these compounds to fight pathogenic bacteria.Methods: The ...  Read More ...

Pulmonary surfactant in COVID-19; A role in etiology and treatment

Myasar Alkotaji; Musab M. Khalaf

Volume 17, Issue 1 , January 2020, Page 115-134

https://doi.org/10.33899/iphr.2020.167601

Abstract
  Introduction: Today, SARS-COV-2 infection represents a global threat. Dealing with this viral infection necessitates a comprehensive understanding of pathophysiology of the disease to reach to the suitable treatment. Treatment of this disease should not be restricted to the usual antiviral treatments, ...  Read More ...