Synthesis and in vitro kinetic study of novel mutual azo prodrug for inflammatory bowel disease

Yasser Fakri Mustafa

Volume 11, Issue 2 , December 2011, Page 1-11

https://doi.org/10.33899/iphr.2011.49649

Abstract
  Background: Inflammatory bowel disease (IBD) refers to idiopathic inflammatory diseases of the intestine, principally ulcerative colitis and Crohn’s disease. IBD is characterized by chronic inflammation in the mucosal membrane of large intestine. 5- ASA is the gold standard for the treatment of ...  Read More ...

Assessment of serum carcinoembryonic antigen in colorectal cancer patients treated by surgery and chemotherapy

Shahbaa A. Al-Bayati

Volume 11, Issue 2 , December 2011, Page 12-16

https://doi.org/10.33899/iphr.2011.49651

Abstract
  Objective: Carcinoembryonic antigen (CEA) is a protein found in many types of cells associated with tumors and the developing fetus. The main use of CEA is as a tumor marker, especially with intestinal cancer. This study was designed to evaluate the effect of surgery and chemotherapy on the level ...  Read More ...

Preparation of modified release diltiazem HCl capsule by complexation with ion exchange resin

Eman B.H. Al-Khedairy; Alaa A. Abdulrasso; Jenan M. AL-Mosawi

Volume 11, Issue 2 , December 2011, Page 17-26

https://doi.org/10.33899/iphr.2011.49655

Abstract
  Background: Diltiazem HCl is a calcium channel blocker drug used in the treatment of angina pectoris and hypertension. Objective: To prepare a sustained release diltiazem HCl capsule by complexation with polystyrene sulfonate strong cation exchange resin (dowex®50wx4) as a complexing and retarding ...  Read More ...

The effect of antioxidant supplementation in the treatment of epilepsy

Nazar A.K. hamid

Volume 11, Issue 2 , December 2011, Page 27-33

https://doi.org/10.33899/iphr.2011.49893

Abstract
  Aim: To assess serum level of malondialdehyde (MDA) and total antioxidant status (TAS) as a representative of oxidative stress in patients with generalized epilepsy and to evaluate the therapeutic effect of the antioxidant (vitamin E and vitamin C) on the levels of MDA,TAS and frequency of seizures ...  Read More ...

The effect of rifampicin and isoniazid on liver and lung tissues in rats

Dalal F. Ahmed

Volume 11, Issue 2 , December 2011, Page 34-45

https://doi.org/10.33899/iphr.2011.49896

Abstract
  Objectives: The purpose of this study was to investigate the histopathological changes in Swiss albino rats liver and lung tissues resulted from the oral administration of the antituberculous drugs rifampicin and isoniazid. Materials and Methods: The study was conducted on 24 adult rats aged 2.5-3 months ...  Read More ...

Effects of estrogen replacement therapy on symptoms and clinical parameters in post menopausal women

Norjihan Ali Shaban; Kawa Dizaye

Volume 11, Issue 2 , December 2011, Page 46-57

https://doi.org/10.33899/iphr.2011.49897

Abstract
  Objective: To evaluate the effect of oral estrogen replacement therapy (ERT) in healthy postmenopausal women on lipid profile, body mass index (BMI), blood pressure, and blood glucose; and on postmenopausal symptoms. Subjects and Methods: This prospective cohort research was carried out over a period of ...  Read More ...

Synthesis of new metoclopramide derivatives and in vitro evaluation of their human cholinesterases protection against Chlorpyrifos

Islam Tarik Qasim; Ahmed A.J. Mahmood; Yasser Fakri Mustafa

Volume 11, Issue 2 , December 2011, Page 58-69

https://doi.org/10.33899/iphr.2011.49900

Abstract
  Objective: The purpose of this study was to synthesize three new derivatives of metoclopramide by diazotization and replacement reactions and then to quantify in vitro their protection effects on blood cholinesterases using chlorpyrifos as a potent inhibitor. methods: The three new metoclopramide ...  Read More ...

Cerebrospinal fluid cholinesterase activity in children with meningitis

Aldeen Alnoori; Mohammed Khalid Jamal

Volume 11, Issue 2 , December 2011, Page 70-76

https://doi.org/10.33899/iphr.2011.49904

Abstract
  Objective: To assess the changes of cerebrospinal fluid (CSF) acetyl cholinesterase (AChE) activity in children with acute bacterial meningitis in comparison to healthy age and sex matched controls. Patients and methods: Out of 41 cases admitted to Alkhansaa pediatric and dilivery hospital (Mosul ...  Read More ...

Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples

Nawal A. Majid; Nief Rahman Ahmad

Volume 11, Issue 2 , December 2011, Page 77-84

https://doi.org/10.33899/iphr.2011.49908

Abstract
  Objective: A simple, sensitive, and accurate indirect spectrophotometric method for the determination of bisacodyl in pure form and in some of its pharmaceutical preparations. Method: The method is based on the oxidation of bisacodyl by iron (III), and subsequent complexation of iron (II) with o-phenanthroline. Results: ...  Read More ...

Detection of Toxoplasma gondii IgM and Cytomegalovirus IgM antibodies among blood donors in Mosul

Karam A. Al-Dabbagh

Volume 11, Issue 2 , December 2011, Page 85-92

https://doi.org/10.33899/iphr.2011.49909

Abstract
  Background: Toxoplasmosis is an infection caused by the protozoan parasite Toxoplasma gondii. This parasite can be transmitted via blood transfusion. Cytomegalovirus (CMV) is a herpes virus that can cause many complications and mostly transfer via blood transfusion. The aim of this study was to evaluate ...  Read More ...

In vitro kinetic study of donepezil N- oxide metabolites

Faris T. Abachi; Ammar B. Behnan; Riyath A. Atto

Volume 11, Issue 2 , December 2011, Page 93-101

https://doi.org/10.33899/iphr.2011.49912

Abstract
  Objective: The aim of this study was to examine the metabolism of donepezil via N – oxidation of donepezil HCl in vitro, and the kinetic studies at a temperature similar to that of the human body. Methods: Direct reaction of donepezil with hydrogen peroxide and formic acid at room temperature, ...  Read More ...

Comparison between quantitative and qualitative biochemical markers in the diagnosis of acute coronary syndrome

Akram J Ahmad; Samir B Al-Mukhtar

Volume 11, Issue 2 , December 2011, Page 102-110

https://doi.org/10.33899/iphr.2011.49916

Abstract
  Objectives: To compare between the qualitative estimation of biochemical markers Point-of-Care testing) with the quantitative estimation of the same markers in the diagnosis of acute coronary syndrome (ACS). Design: Case-series study. Setting: This study was carried out in coronary care unit in Ibn- ...  Read More ...

Serum immunoglobulin levels in male schizophrenic patients before and after olanzapine therapy

Mahmoud Khudhayer Oglah Hussein

Volume 11, Issue 2 , December 2011, Page 111-114

https://doi.org/10.33899/iphr.2011.49919

Abstract
  Objective: To evaluate the effect of olanzapine therapy on serum immunoglobulin levels (IgA, IgG, IgM) in male schizophrenic patients after 2 months of treatment by olanzapine at a daily dose of 20 mg. Patients and Methods: Twenty-eight patients with schizophrenia were included in this study, assessment ...  Read More ...