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Iraqi Journal of Pharmacy

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Effects of valsartan vs captopril on some renal function tests in hypertensive patients

    Shamil Hashim Othman

Iraqi Journal of Pharmacy, 2012, Volume 12, Issue 1, Pages 56-64
10.33899/iphr.2012.62344

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Abstract

Objectives: To investigate the effects of valsartan and captopril on some renal function tests (RFTs) in patients with essential hypertension.
Patients and methods: A total of 40 patients with stage I essential hypertension were recruited and investigated for RFTs which include, blood urea, serum creatinine, creatinine clearance, serum sodium and serum potassium. The patients were divided into 2 groups, namely the valsartan group which consisted of 20 patients and the captopril group which consisted of 20 patients. The patient groups were followed- up for 8 weeks during which RFTs were measured before starting therapies and at the end of the follow-up period using commercially available kits. The patient groups were compared with a control group consisted of 30 apparently healthy subjects.
Results: The RFTs at baseline in both patient groups were found elevated as compared to the control group (p < 0.001), except for serum potassium concentration which was comparable . The RFTs in patient groups were comparable before and after therapies.
Conclusion: The use of valsartan and captopril for 8 weeks in hypertensive patients has no adverse effects on RFTs.
Keywords:
    hypertension Valsartan captopril renal function tests
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(2012). Effects of valsartan vs captopril on some renal function tests in hypertensive patients. Iraqi Journal of Pharmacy, 12(1), 56-64. doi: 10.33899/iphr.2012.62344
Shamil Hashim Othman. "Effects of valsartan vs captopril on some renal function tests in hypertensive patients". Iraqi Journal of Pharmacy, 12, 1, 2012, 56-64. doi: 10.33899/iphr.2012.62344
(2012). 'Effects of valsartan vs captopril on some renal function tests in hypertensive patients', Iraqi Journal of Pharmacy, 12(1), pp. 56-64. doi: 10.33899/iphr.2012.62344
Effects of valsartan vs captopril on some renal function tests in hypertensive patients. Iraqi Journal of Pharmacy, 2012; 12(1): 56-64. doi: 10.33899/iphr.2012.62344
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