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Iraqi Journal of Pharmacy

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The effect of metformin on some liver function tests in type 2 diabetic patients

    Islam T.Q. AI-Mola Faris A. Ahmed

Iraqi Journal of Pharmacy, 2006, Volume 6, Issue 1, Pages 25-27
10.33899/iphr.2006.50554

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Abstract

Objectives: To study the effect of metformin on serum glucose and some liver function tests
including serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate
aminotransferase (AST) and bilirubin in type 2 diabetic patients.
Design: Case-control study.
Setting: The study was carried out in Al-Waffa centre for diabetes in Mosul, during the period
from March 2004 to December 2004.
Participants: Fifty type 2 diabetic patients treated with metformin were included. In addition,
two control groups were used, 50 nontreated diabetic patients and 50 apparently healthy
subjects.
Results: Serum glucose in metformin treated diabetics -was lower (P<0.05) than the nontreated
diabetics; however, ALP and ALT were higher (P<0.05) in the treated diabetics. At the same
time, AST and bilirubin did not change by metformin by using Duncan test.
Conclusion: Metformin causes increase in some liver function tests. Therefore, patients treated
with metformin should be periodically examined for the liver function tests.
Keywords:
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(2006). The effect of metformin on some liver function tests in type 2 diabetic patients. Iraqi Journal of Pharmacy, 6(1), 25-27. doi: 10.33899/iphr.2006.50554
Islam T.Q. AI-Mola; Faris A. Ahmed. "The effect of metformin on some liver function tests in type 2 diabetic patients". Iraqi Journal of Pharmacy, 6, 1, 2006, 25-27. doi: 10.33899/iphr.2006.50554
(2006). 'The effect of metformin on some liver function tests in type 2 diabetic patients', Iraqi Journal of Pharmacy, 6(1), pp. 25-27. doi: 10.33899/iphr.2006.50554
The effect of metformin on some liver function tests in type 2 diabetic patients. Iraqi Journal of Pharmacy, 2006; 6(1): 25-27. doi: 10.33899/iphr.2006.50554
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