Mosul University
  • Register
  • Login
  • العربیة

Iraqi Journal of Pharmacy

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 5, Issue 1
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Peer Review Process

News

Guide to reviwers

Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress

    M.K. Shindala S.M. A. AL-Nuimi

Iraqi Journal of Pharmacy, 2005, Volume 5, Issue 1, Pages 53-58
10.33899/iphr.2005.50264

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

The immobilization stress has been recently recognized to produce marked increase of gastric acid secretion and cause hyperaemia in the stomach . Since ranitidine reduced corpus mucosal blood flow in the stomach to basal levels, it may cause suppression of hyperaemia induced by immobilization stress. In this study, 5 groups of 5 rats each were used. The extent of hyperaemia in the glandular mucosa of the stomach of control rats (pretreated with saline) exposed to stress was compared with ranitidine treatment 30 minutes before onset of stress. Gastric hyperaemia elicited in the control rats, while treatment with ranitidine (20 and 40 mg/kg i.m.) 30 minutes before onset of stress, caused a dose – dependent reduction in the gastric hyperaemia response to stress. Furthermore, pretreatment with ranitidine in different doses did not suppress the increase in alanine amino transferase (ALT) activity induced by stress as well as there was no significant difference between plasma cholesterol level in all investigated groups. In conclusion, the present study demonstrates that gastric damage produced by immobilization stress can be protected by ranitidine.
Keywords:
  • PDF
  • XML
(2005). Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress. Iraqi Journal of Pharmacy, 5(1), 53-58. doi: 10.33899/iphr.2005.50264
M.K. Shindala; S.M. A. AL-Nuimi. "Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress". Iraqi Journal of Pharmacy, 5, 1, 2005, 53-58. doi: 10.33899/iphr.2005.50264
(2005). 'Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress', Iraqi Journal of Pharmacy, 5(1), pp. 53-58. doi: 10.33899/iphr.2005.50264
Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress. Iraqi Journal of Pharmacy, 2005; 5(1): 53-58. doi: 10.33899/iphr.2005.50264
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 214
  • PDF Download: 77
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus