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Iraqi Journal of Pharmacy

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The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients

    Jawna Khalid Mamdoh Faris A. Ahmed

Iraqi Journal of Pharmacy, 2005, Volume 5, Issue 1, Pages 40-45
10.33899/iphr.2005.50260

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Abstract

Objectives: To assess the effect of atenolol and combination of atenolol and diuresam (hydrochlorthiazide, 25 mg and amiloride, 5 mg) on the lipid profile including serum total cholesterol, triglyceride, very low density lipoprotein-cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in hypertensive patients.
Design: Case-control study.
Setting: The study was conducted in Outpatient department of Ibn-Senna Hospital in Mosul, during the period from December 2003 to July 2004.
Participants: Fifty hypertensive patients under atenolol therapy (100 mg/day) and 40 hypertensive patients under combination therapy of atenolol (100 mg/day) and diuresam (one tablet every other day). In addition to that, 50 stage 1 hypertensive patients without treatment served as a control group.
Mean outcome measures: lipid profile in the treated hypertensive patients were compared with those measurements in the control group by using Duncan test.
Results: In the hypertensive patients treated with atenolol, serum total cholesterol, triglyceride, VLDL-C and LDL-C were significantly higher (P<0.05) than those values in the control group, at the same time HDL-C did not change. The measurements of the lipid profile of the atenolol group were not significantly different from those measurements in the combination treated group of atenolol and diuresam.
Conclusion: Chronic use of atenolol or combination of atenolol and diuresam is associated with a significant increase in serum lipid profile. However, diuresam in moderate dose might not increase serum lipid profile.
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(2005). The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients. Iraqi Journal of Pharmacy, 5(1), 40-45. doi: 10.33899/iphr.2005.50260
Jawna Khalid Mamdoh; Faris A. Ahmed. "The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients". Iraqi Journal of Pharmacy, 5, 1, 2005, 40-45. doi: 10.33899/iphr.2005.50260
(2005). 'The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients', Iraqi Journal of Pharmacy, 5(1), pp. 40-45. doi: 10.33899/iphr.2005.50260
The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients. Iraqi Journal of Pharmacy, 2005; 5(1): 40-45. doi: 10.33899/iphr.2005.50260
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