Iraqi Journal of Pharmacy

Abstract

Objectives: (a) To determine the change in the lipid profile, β-lipoprotein shift ratio (B-LSR) and serum fasting glucose (SG) in metabolic syndrome( MS) and control.(b) To determine the effects of age and body mass index (BMI) on the measured parameters.
Methods: This study was conducted in AL-Darkeslea area in Mosul province. during the period from January to April 2007. Fasting blood samples were collected from100 patients, 60 patients with metabolic syndrome MS according to WHO criteria and 40 apparently healthy subjects. The collected data were analysed by 2- sample t-test and the effects of the age and BMI on the measured parameters were determined by correlation coefficient.
Results: B-LSR was higher in MS patients than in the control group (P<0.001), Total serum cholesterol (TC), triglycerides (TG), Low density lipoprotein-cholesterol (LDL-C), Very low density lipoprotein-cholesterol (VLDL-C) and atherogenic index (AI)showed significant increases in MS patients when compared to the controls (P< 0.05), while serum high density lipoprotein-cholesterol (HDL-C) showed significant reduction in MS than controls (P<0.001), also SG showed same increase (P<0.001).TC and LDL-C were significantly correlated with the age in controls while no significant correlation were seen in the MS patients. No significant correlation was noticed between BMI and the measured parameters, in both MS patients and control group.
Conclusion: MS is associated with significant changes in B-LSR, lipid profile and SG. Age and BMI showed no significant correlation with theses parameters in the MS patients.