Synergistic activity of azithromycin combined with metronidazole against toxoplasmosis in experimental mice
AbstractObjective: To evaluate the efficacy of synergistic activity of azithromycin combined with metronidazole against toxoplasmosis experimentally induced in murine model.
Material & Methods: Albino mice model (balb/c mice) acutly infected with tachyzoites, were treated for 10days from day +1 postinfection with administration of azithromycin combined with metronidazol.
Results: The results showed that prolonged survival of albino mice relative to that of untreated control, and the dead mice were found only in the control group. This experiment showed that a remarkable synergistic effect on toxoplasmosis was obsereved when azithromycin was adminstratered in combination with metronidazole at cuurative dosage i.e.(250 and 200 mg/kg/day), respectively. These results showed that azithromycin, which is remarkably active on toxoplasmosis, significantly potentiates the curative effect of metronidazol in the treatment. The treated mice in uncontrolled group were completely cured from toxoplasmosis as their brain were free of T. gondii cyst either microscopically or by bioassay.
Conclusion: Combined drugs of azithromycin and metronidazole showed a cure rate of 100% in experimental murine toxoplasmosis.
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