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Iraqi Journal of Pharmacy

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Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples

    Nawal A. Majid Nief Rahman Ahmad

Iraqi Journal of Pharmacy, 2011, Volume 11, Issue 2, Pages 77-84
10.33899/iphr.2011.49908

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Abstract

Objective: A simple, sensitive, and accurate indirect spectrophotometric method for
the determination of bisacodyl in pure form and in some of its pharmaceutical
preparations.
Method: The method is based on the oxidation of bisacodyl by iron (III), and
subsequent complexation of iron (II) with o-phenanthroline.
Results: Forming a red-colored complex (ferroin) having the maximum absorbance at
510 nm. Beer’s law is obeyed in the concentration range of 0.5-5 µg/ml. The molar
absorptivity and sandell’s sensitivity were 1.55×104 L.mol-1.cm-1 and 0.0233µg.cm-2
respectively. The relative standard deviation (RSD) was less than 1.5 (n=11). The
limits of detection and quantitation are 0.083 and 0.25 µg.ml-1 respectively.
Conclusion: The method is applied successfully for determination of bisacodyl in
environmental water samples and in some pharmaceutical formulations (tablets and
suppositories). A statistical comparison of these results with those of official method
shows good agreement and indicates no significant difference in the precision.
Keywords:
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(2011). Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples. Iraqi Journal of Pharmacy, 11(2), 77-84. doi: 10.33899/iphr.2011.49908
Nawal A. Majid; Nief Rahman Ahmad. "Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples". Iraqi Journal of Pharmacy, 11, 2, 2011, 77-84. doi: 10.33899/iphr.2011.49908
(2011). 'Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples', Iraqi Journal of Pharmacy, 11(2), pp. 77-84. doi: 10.33899/iphr.2011.49908
Indirect spectrophotometric method for the determination of bisacodyl in commercial dosage forms and in environmental water samples. Iraqi Journal of Pharmacy, 2011; 11(2): 77-84. doi: 10.33899/iphr.2011.49908
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