Iraqi Journal of Pharmacy

Abstract

Objective: To assess the changes of cerebrospinal fluid (CSF) acetyl cholinesterase
(AChE) activity in children with acute bacterial meningitis in comparison to healthy
age and sex matched controls.
Patients and methods: Out of 41 cases admitted to Alkhansaa pediatric and dilivery
hospital (Mosul city) between January 2010 and July 2010, 28 cases proved to be a
case of Haemophilus influenzae meningitis, 13 child proved lack from any type of
meningitis with age and sex matched subjects taken as a control group. Initially from
all of the studied children (patients and controls) about 5 ml CSF samples were taken
and assayed for appearance, leucocytes, red blood cells, sugar, protein and AChE
activities by spectrophotometric method.
Results: There were a significant increase in CSF WBCs count, RBCs count, protein
levels, AChE activity with a decrease in CSF glucose level for children with acute
bacterial meningitis in comparison to the control group.
Conclusion: There is an important value for measurement of CSF AChE activity for
confidential diagnosis of children with acute bacterial meningitis specially for those
with equivocal decision by using the traditional parameters.