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The effect of antioxidant supplementation in the treatment of epilepsy

    Nazar A.K. hamid

Iraqi Journal of Pharmacy, 2011, Volume 11, Issue 2, Pages 27-33
10.33899/iphr.2011.49893

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Abstract

Aim: To assess serum level of malondialdehyde (MDA) and total antioxidant status
(TAS) as a representative of oxidative stress in patients with generalized epilepsy and
to evaluate the therapeutic effect of the antioxidant (vitamin E and vitamin C) on the
levels of MDA,TAS and frequency of seizures attacks after two months therapy. for a
period of two months as a supplementation therapy.
Subjects and Methods: The study was conducted in Iben-seena Hospital in Mosul
city-Iraq. Fifty three patients with generalized epilepsy were included in this study
(32 male and 21 female). The study included 40 apparently healthy subjects, age and
sex matched as a control group. Initially from both the patients and controls, blood
samples were taken. Another blood samples were taken from the patients 2 months
after vitamin E and vitamin C treatment, blood samples were analysed for serum
MDA and serum TAS.
Result: Serum MDA was found to be significantly higher ( P<0.001) and serum TSA
was significantly lower (P<0.001) in patients with generalized epilepsy prior vitamin
E and vitamin C supplementation in comparison to controls. After vitamin E and C
supplementation there was a significant reduction (P<0.001) in the serum MDA levels
with a significant increase (P<0.001) in the serum TAS. Also we found a reduction in
seizure frequency of greater than 70% after vitamin E and C supplementation.
Conclusion: a significant reduction of TSA was reported in patients with epilepsy.
Administration of vitamin E and C produced a significant reduction of serum MAD
levels and a significant elevation of serum TAS, associated with a reduction of greater
than 70% of seizure frequency. The study suggests the administration of vitamin E
and C as adjunct to antiepileptic drugs.
Keywords:
    Epilepsy oxidant vitamin E vitamin C
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(2011). The effect of antioxidant supplementation in the treatment of epilepsy. Iraqi Journal of Pharmacy, 11(2), 27-33. doi: 10.33899/iphr.2011.49893
Nazar A.K. hamid. "The effect of antioxidant supplementation in the treatment of epilepsy". Iraqi Journal of Pharmacy, 11, 2, 2011, 27-33. doi: 10.33899/iphr.2011.49893
(2011). 'The effect of antioxidant supplementation in the treatment of epilepsy', Iraqi Journal of Pharmacy, 11(2), pp. 27-33. doi: 10.33899/iphr.2011.49893
The effect of antioxidant supplementation in the treatment of epilepsy. Iraqi Journal of Pharmacy, 2011; 11(2): 27-33. doi: 10.33899/iphr.2011.49893
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