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Iraqi Journal of Pharmacy

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Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus

    Najlaa Saadi Ismail

Iraqi Journal of Pharmacy, 2011, Volume 11, Issue 1, Pages 69-74
10.33899/iphr.2011.49595

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Abstract

Objectives: To assess the effect of glibenclamide and metformin on serum uric acid level in
patients with type ٢ diabetes.
Study design: Case control study.
Subjects and Methods: This study was conducted from March ٢٠٠٩ to January ٢٠١٠.
Fasting blood sugar and serum uric acid level were measured in patients suffering from type-
٢ diabetes mellitus who were referred to Al-Wafa Diabetic Center in Mosul City. Group ١: ٣٢
patients on glibenclamide therapy, group ٢: ٤٢ patients on metformin therapy and group ٣: ٤٢
patients on combination therapy, group ٤: ٣٢ patients on restricted diet, and ٢٣ apparently
healthy volunteers, were taken as a control group.
Results: The study showed a significant increase in the serum uric acid level of the diabetic
patients as compared with the control. Glibenclamide and/or metformin showed no significant
difference in the serum uric acid level in patients with type ٢ diabetes mellitus.
Conclusion: Glibenclamide and/or metformin had no significant effect on serum uric acid
level in patients with type ٢ diabetes mellitus.
Keywords:
    Uric acid Hyperuricemia type Glibenclamide metformin
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(2011). Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus. Iraqi Journal of Pharmacy, 11(1), 69-74. doi: 10.33899/iphr.2011.49595
Najlaa Saadi Ismail. "Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus". Iraqi Journal of Pharmacy, 11, 1, 2011, 69-74. doi: 10.33899/iphr.2011.49595
(2011). 'Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus', Iraqi Journal of Pharmacy, 11(1), pp. 69-74. doi: 10.33899/iphr.2011.49595
Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus. Iraqi Journal of Pharmacy, 2011; 11(1): 69-74. doi: 10.33899/iphr.2011.49595
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