Iraqi Journal of Pharmacy

Abstract

Objectives: To assess the effect of glibenclamide and metformin on serum uric acid level in
patients with type ٢ diabetes.
Study design: Case control study.
Subjects and Methods: This study was conducted from March ٢٠٠٩ to January ٢٠١٠.
Fasting blood sugar and serum uric acid level were measured in patients suffering from type-
٢ diabetes mellitus who were referred to Al-Wafa Diabetic Center in Mosul City. Group ١: ٣٢
patients on glibenclamide therapy, group ٢: ٤٢ patients on metformin therapy and group ٣: ٤٢
patients on combination therapy, group ٤: ٣٢ patients on restricted diet, and ٢٣ apparently
healthy volunteers, were taken as a control group.
Results: The study showed a significant increase in the serum uric acid level of the diabetic
patients as compared with the control. Glibenclamide and/or metformin showed no significant
difference in the serum uric acid level in patients with type ٢ diabetes mellitus.
Conclusion: Glibenclamide and/or metformin had no significant effect on serum uric acid
level in patients with type ٢ diabetes mellitus.