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Iraqi Journal of Pharmacy

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Chemical and biopharmaceutical assay of different brands of frusemide tablets

    Thamer A. Amar Mahmood K. Oglah Musab M. Khalaf

Iraqi Journal of Pharmacy, 2011, Volume 11, Issue 1, Pages 6-12
10.33899/iphr.2011.49573

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Abstract

Objective: To evaluate the chemical and biopharmaceutical equivalence of frusemide tablets
from ٥ different companies.
Methods: This study was conducted on five brands of frusemide tablets available in the
pharmacies of Mosul city from different manufacturing companies. These brands have been
evaluated using some quality control tests of uniformity of weight, hardness, disintegration
time, dissolution rate determination for the tablets.
Results: The results obtained have been discussed in some detail using monographs in the
United State Pharmacopeia (USP) and British Pharmacopeia (BP). All the brands content were
within the acceptable range of USP (٩٠-١١٠ %), the disintegration time of all the brands also
within the range of the USP and BP. . The dissolution profile also were within the acceptable
range of USP not less than ٨٠% of the labeled amount of frusemide is dissolved in ٦٠ minutes.
Conclusion: All the brands tested in this study may be used interchangeably.
Keywords:
    Bioequivalence dissolution disintegration frusemide quality control
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(2011). Chemical and biopharmaceutical assay of different brands of frusemide tablets. Iraqi Journal of Pharmacy, 11(1), 6-12. doi: 10.33899/iphr.2011.49573
Thamer A. Amar; Mahmood K. Oglah; Musab M. Khalaf. "Chemical and biopharmaceutical assay of different brands of frusemide tablets". Iraqi Journal of Pharmacy, 11, 1, 2011, 6-12. doi: 10.33899/iphr.2011.49573
(2011). 'Chemical and biopharmaceutical assay of different brands of frusemide tablets', Iraqi Journal of Pharmacy, 11(1), pp. 6-12. doi: 10.33899/iphr.2011.49573
Chemical and biopharmaceutical assay of different brands of frusemide tablets. Iraqi Journal of Pharmacy, 2011; 11(1): 6-12. doi: 10.33899/iphr.2011.49573
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