Document Type : Review Paper

Authors

1 Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq

2 Department of Clinical Laboratory Sciences, College of Pharmacy, University of Mosul, Mosul, Iraq

Abstract

Background: Exposure to both synthetic and naturally occurring chemical substances can cause a wide range of reactions such as Drug-Induced Liver Injury(DILI). It is a serious problem due to the increasing number of substances being used for the treatment of different illnesses, coupled with the growing popularity of herbal products encourage self-medication but are not strictly regulated. It can be challenging to predict, diagnose, and treat (DILI) due to the wide range of underlying mechanisms and risk factors. DILI can range in severity from moderate transaminase elevation to potentially fatal acute liver failure. Aim: The purpose of this review article is to gain a better understanding of DILI , which includes its causes, classification, the more toxic medications, and chemicals that can lead to DILI. The purpose also covers the biomarkers and liver function tests that can help identify this condition, as well as the substances that are commonly used for liver protection. Methods: We made a worldwide search through well-known online databases such as PubMed, Science Direct, Elsevier, and others to keep going with related liver disease trials that have been approved in previous years. Conclusion: DILI is one of the leading causes of liver disease globally, resulting from the use of prescription, over-the-counter, and herbal medications. Due to the lack of a single clinical, laboratory, or histologic characteristic specific to the illness, diagnosing DILI can be challenging.For an accurate diagnosis, it is essential to establish a causal correlation between the suspected substances and other causes of liver injury.

Highlights

  • Drug-induced liver injury (DILI) is a significant issue due to the growing number of drugs used to treat different diseases.
  • The mechanisms underlying DILI include immune-mediated damage and mitochondrial dysfunction.
  • The use of certain products obtained from herbels is required for the prevention of drug-induced liver injury.

Keywords

Main Subjects

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