Document Type : Research Paper

Authors

1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ninevah, Mosul, Iraq

2 Department of Laboratory, Al-Hadbaa Blood and Bone Marrow Transplantation Hospital, Mosul, Iraq

Abstract

Background: As a key regulator of bone metabolism, parathyroid hormone (PTH) also modulates the homeostatic response to changes in plasma calcium concentrations. PTH values are often used in patients with “chronic kidney disease (CKD)” as a surrogate for assessing bone and mineral disease associated with CKD. Objectives: The present study sought to evaluate the PTH level alongside measured serum electrolytes and renal function in CKD patients. Method: This study was based on a cross-sectional comparative study which considered the sample size of 120 individuals who were divided into two groups, the control group (n=30) which had apparently healthy individuals, and the second group which consisted of (n=90) patients diagnosed with CKD, and associated medical conditions including hypertension and diabetes. Parathyroid hormone, calcium, phosphate, fasting blood sugar, creatinine, blood urea, serum sodium were measured. Results: The results summarize that the levels of PTH, FBS, phosphate, urea, and creatinine were significantly increased in the patients with CKD as compared to the healthy individuals. However, no marked differences were found in the values of Na, K, and Ca. Conclusion: PTH should be considered as a marker for CKD and outlined in the investigation and follow-up of the prognosis of these patients.

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Main Subjects

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