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Therapeutic Potential of Epigallocatechin-3-gallate as a DYRK1A Inhibitor in Diabetes Mellitus: An Overview

Document Type : Review Paper

Authors

1 Department of Pharmacology, College of Pharmacy, University of Mosul , Mosul, Iraq

2 Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq

10.33899/iphr.2023.141712.1048

Abstract

Background: Diabetes mellitus is a common metabolic disorder characterized by chronic high blood sugar levels due to impaired insulin secretion or action. Existing diabetic medications have limitations, including high costs and the risk of hypoglycemia. Aim: To overcome these challenges, researchers are exploring advanced treatments, and one potential path is studying plants and natural sources. Many plants include green tea (Camellia sinensis), rich in catechin derivatives, particularly epigallocatechin-3-gallate (EGCG), have shown promising effect because this agent may enhance beta cell proliferation, so it can produce dramatic response in management of diabetes mellitus and it is expected to reduce complication of this disease. Thorough data searching from September 2021 to June 2023 was used to conduct this study. The key terms diabetes mellitus, herbal treatment of diabetes, DYRK1A inhibitor, Epigallocatechin-3-gallate, and beta cell proliferation were concomitantly searched in Google Scholar, Web of Science, and PubMed in order to find relevant material. The publications that are presented here were published between 2014 and 2023. Conclusion: Collectively EGCG properties as a DYRK1A inhibitor may enhance β cell proliferation that is promising effects in diabetes mellitus treatment.

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Iraqi Journal of Pharmacy

Articles in Press, Accepted Manuscript
Available Online from 14 September 2023
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  • Receive Date: 11 July 2023
  • Revise Date: 12 September 2023
  • Accept Date: 14 September 2023
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