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Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes

Document Type : Review Paper

Authors

1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

2 Pharmaceutical Chemistry Department, College of Pharmacy, Mosul University, Nineveh, Iraq

10.33899/iphr.2023.142709.1054

Abstract

Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which have been instrumental in the creation of coumarin chemistry. Cou-Ds are a unique class of bioactive candidates with novel therapeutic attributes due to their bacteriostatic, antifungal, antioxidant, anticancer, antidepressant, and other pharmacological properties. In addition to their biomedical uses, the literature illustrates the uses of Cou-Ds from a material point of view, such as those in food additives, fragrances, beauty products, optical brighteners, and would disperse fluorescent and laser dyes. Numerous optical purposes using Cou-Ds have been thoroughly investigated. A wide range of natural sources and newly created Cou-Ds are being isolated or produced at a growing rate. The procedures of synthesis and therapeutic uses of Cou-Ds in the treatment of various illnesses were critically found in many published papers. Aim: The aim of this review article is to highlight the most up-to-date information about Cou-Ds and clarify the various natural sources, synthetic strategies, reactions, biological activity, and different pharmaceutical applications of Cou-Ds. Conclusion: From the collected and discussed reviewing information, the authors concluded that the Cou-Ds can open the drug development door for producing more potent, biosafe medicines.

Keywords

Main Subjects

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Iraqi Journal of Pharmacy

Articles in Press, Accepted Manuscript
Available Online from 13 September 2023
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  • Receive Date: 17 August 2023
  • Revise Date: 06 September 2023
  • Accept Date: 13 September 2023
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