Document Type : Review Paper


1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

2 Pharmaceutical Chemistry Department, College of Pharmacy, Mosul University, Nineveh, Iraq



Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which have been instrumental in the creation of coumarin chemistry. Cou-Ds are a unique class of bioactive candidates with novel therapeutic attributes due to their bacteriostatic, antifungal, antioxidant, anticancer, antidepressant, and other pharmacological properties. In addition to their biomedical uses, the literature illustrates the uses of Cou-Ds from a material point of view, such as those in food additives, fragrances, beauty products, optical brighteners, and would disperse fluorescent and laser dyes. Numerous optical purposes using Cou-Ds have been thoroughly investigated. A wide range of natural sources and newly created Cou-Ds are being isolated or produced at a growing rate. The procedures of synthesis and therapeutic uses of Cou-Ds in the treatment of various illnesses were critically found in many published papers. Aim: The aim of this review article is to highlight the most up-to-date information about Cou-Ds and clarify the various natural sources, synthetic strategies, reactions, biological activity, and different pharmaceutical applications of Cou-Ds. Conclusion: From the collected and discussed reviewing information, the authors concluded that the Cou-Ds can open the drug development door for producing more potent, biosafe medicines.


Main Subjects

  1. Jebir RM, Mustafa YF. Natural Coumarin-Lead Compounds: A Review of Their Medicinal Potentials. Iraqi Journal of Pharmacy 2022;18(2):139–61.
  2. Waheed SA, Mustafa YF. Synthesis of coumarin-based derivatives from different starting materials: A review of ongoing developments. Iraqi Journal of Pharmacy 2022;18(2):126–38.
  3. Oglah MK, Mustafa YF, Bashir MK, Jasim MH. Curcumin and its derivatives: A review of their biological activities. Systematic Reviews in Pharmacy 2020;11(3):472–81.
  4. Jasim SF, Mustafa YF. A review on coumarin backbone: An attractive scaffold for promising bioactive compounds. Iraqi Journal of Pharmacy 2022;18(2):104–25.
  5. Ismael RN, Mustafa YF, Al-Qazaz HK. Coumarin-based products: Their biodiversity and pharmacology. Iraqi Journal of Pharmacy 2022;18(2):162–79.
  6. Mustafa YF, Waheed SA, Jasim SF, Jebir RM, Ismael RN, Qutachi O. A Narrative Review of Benzo-Fused Coumarins, Shedding Light on Their Medicinal Activities. Iraqi Journal of Pharmacy 2023;20(1):7–16.
  7. Akendengue B, Ngou-Milama E, Bourobou-Bourobou H, Essouma J, Roblot F, Gleye C, et al. Acaricidal activity of Uvaria versicolor and Uvaria klaineana (Annonaceae). Phytotherapy Research 2003;17(4):364–7.
  8. Mustafa YF. Chemotherapeutic applications of folate prodrugs: A review. NeuroQuantology 2021;19(8):99–112.
  9. Mahmood AAJ, Mustafa YF, Abdulstaar M. New coumarinic azo-derivatives of metoclopramide and diphenhydramine: Synthesis and in vitro testing for cholinesterase inhibitory effect and protection ability against chlorpyrifos. International Medical Journal Malaysia 2014;13(1):3–12.
  10. Mustafa YF, Abdulaziza NT, Jasima MH. 4-Methylumbelliferone and its derived compounds: A brief review of their cytotoxicity. Egyptian Journal of Chemistry 2021;64(4):1807–16.
  11. Mustafa YF, Abdulaziz NT. Hymecromone and its products as cytotoxic candidates for brain cancer : A brief review. NeuroQuantology 2021;19(7):175–86.
  12. Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A, Henichart JP. Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Natural Product Research 2006;20(10):909–16.
  13. Mustafa YF, Al - dabbagh KA, Mohammed MF. Synthesis of new metronidazole derivatives with suspected antimicrobial activity. Iraqi Journal of Pharmacy 2008;7(1):34–41.
  14. Mohammed ET, Mustafa YF. Coumarins from Red Delicious apple seeds: Extraction, phytochemical analysis, and evaluation as antimicrobial agents. Systematic Reviews in Pharmacy 2020;11(2):64–70.
  15. Satyanarayana VSV, Sreevani P, Sivakumar A, Vijayakumar V. Synthesis and antimicrobial activity of new Schiff bases containing coumarin moiety and their spectral characterization. Arkivoc 2008;2008(17):221–33.
  16. Mustafa YF, Khalil RR, Mohammed ET. Antimicrobial activity of aqueous extracts acquired from the seeds of two apples’ cultivars. Systematic Reviews in Pharmacy 2020;11(2):382–7.
  17. Mustafa YF, Abdulaziz NT. Biological potentials of hymecromone-based derivatives: A systematic review. Systematic Reviews in Pharmacy 2020;11(11):438–52.
  18. Sashidhara K V., Modukuri RK, Singh S, Bhaskara Rao K, Aruna Teja G, Gupta S, et al. Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity. Bioorganic and Medicinal Chemistry Letters 2015;25(2):337–41.
  19. Mustafa YF. Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates. Applied Nanoscience (Switzerland) 2023;13(3):1907–18.
  20. Channar PA, Irum H, Mahmood A, Shabir G, Zaib S, Saeed A, et al. Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase. Bioorganic Chemistry 2019;91:103137.
  21. Nofal ZM, El-Zahar MI, Abd El-Karim SS. Novel coumarin derivatives with expected biological activity. Molecules 2000;5(2):99–113.
  22. Khalil RR, Mustafa YF. Phytochemical, antioxidant and antitumor studies of coumarins extracted from Granny Smith apple seeds by different methods. Systematic Reviews in Pharmacy 2020;11(2):57–63.
  23. Kontogiorgis C, Hadjipavlou-Litina D. Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents. Journal of Enzyme Inhibition and Medicinal Chemistry 2003;18(1):63–9.
  24. Al-Amiery AA, Musa AY, Kadhum AAH, Mohamad AB. The use of umbelliferone in the synthesis of new heterocyclic compounds. Molecules 2011;16(8):6833–43.
  25. Ooyama Y, Ishii A, Kagawa Y, Imae I, Harima Y. Dye-sensitized solar cells based on novel donor-acceptor π-conjugated benzofuro[2,3-c]oxazolo[4,5-a]carbazole-type fluorescent dyes exhibiting solid-state fluorescence. New Journal of Chemistry 2007;31(12):2076–82.
  26. Lin SL, Kuo PY, Yang DY. Design and synthesis of a coumarin-based acidichromic colorant. Molecules 2007;12(7):1316–24.
  27. Ray D, Bharadwaj PK. A coumarin-derived fluorescence probe selective for magnesium. Inorganic Chemistry 2008;47(7):2252–4.
  28. Cohen SM, Ellwein LB. Genetic Errors, Cell Proliferation, and Carcinogenesis. Cancer Research 1991;51(24):6493–505.
  29. Vassallo JD, Hicks SM, Daston GP, Lehman-McKeeman LD. Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity. Toxicological Sciences 2004;80(2):249–57.
  30. Mustafa YF. Synthesis, characterization and antibacterial activity of novel heterocycle, coumacine, and two of its derivatives. Saudi pharmaceutical journal 2018;26(6):870–5.
  31. Mustafa YF. Synthesis, characterization and preliminary cytotoxic study of sinapic acid and its analogues. Journal of Global Pharma Technology 2019;11(9):1–10.
  32. Yahaya I, Seferoğlu N, Seferoğlu Z. Improved one-pot synthetic conditions for synthesis of functionalized fluorescent coumarin-thiophene hybrids: Syntheses, DFT studies, photophysical and thermal properties. Tetrahedron 2019;75(14):2143–54.
  33. Mustafa YF, Khalil RR, Mohammed ET. Synthesis and antitumor potential of new 7-halocoumarin-4-acetic acid derivatives. Egyptian Journal of Chemistry 2021;64(7):3711–6.
  34. Kohn MH, Price RE, Pelz HJ. A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats. Artery Research 2008;2(4):138–47.
  35. Guilet D, Séraphin D, Rondeau D, Richomme P, Bruneton J. Cytotoxic coumarins from Calophyllum dispar. Phytochemistry 2001;58(4):571–5.
  36. Bailly C. Lamellarins, from A to Z: A family of anticancer marine pyrrole alkaloids. Current Medicinal Chemistry - Anti-Cancer Agents 2004;4(4):363–78.
  37. Shen L, Xie N, Yang B, Hu Y, Zhang Y. Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents. European Journal of Medicinal Chemistry 2014;85(Figure 1):807–17.
  38. Herschhorn A, Lerman L, Weitman M, Gleenberg IO, Nudelman A, Hizi A. De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants. Journal of Medicinal Chemistry 2007;50(10):2370–84.
  39. Musa M, Cooperwood J, Khan MO. A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer. Vol. 15, Current Medicinal Chemistry. 2008. 2664–2679 p.
  40. Laure F, Raharivelomanana P, Butaud JF, Bianchini JP, Gaydou EM. Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands. Analytica Chimica Acta 2008;624(1):147–53.
  41. Miglietta A, Bocca C, Gabriel L, Rampa A, Bisi A, Valenti P. Antimicrotubular and cytotoxic activity of geiparvarin analogues, alone and in combination with paclitaxel. Cell Biochemistry and Function 2001;19(3):181–9.
  42. Mustafa YF, Bashir MK, Oglah MK. Original and innovative advances in the synthetic schemes of coumarin-based derivatives: A review. Systematic Reviews in Pharmacy 2020;11(6):598–612.
  43. Mustafa YF. Classical approaches and their creative advances in the synthesis of coumarins: A brief review. Journal of Medicinal and Chemical Sciences 2021;4(6):612–25.
  44. Artuç GÖ, Altındal A, Eran BB, Bulut M. Synthesis, characterization and ethanol sensing properties of peripheral and non-peripheral tetrakis-(3,6-dihexyl-7-oxy-4-methylcoumarin)substituted zinc(II), cobalt(II), and copper(II) phthalocyanines. Dyes and Pigments 2019;171(July):107741.
  45. Vahabi V, Hatamjafari F. Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products. Molecules 2014;19(9):13093–103.
  46. Smitha G, Reddy CS. Synthetic Communications : An International Journal for Rapid Communication of Synthetic Organic Chemistry ZrCl 4 ‐ Catalyzed Pechmann Reaction : Synthesis of Coumarins Under Solvent ‐ Free Conditions. 2013;(June 2013):37–41.
  47. Albadi J, Shirini F, Abasi J, Armand N, Motaharizadeh T. A green, efficient and recyclable poly(4-vinylpyridine)-supported copper iodide catalyst for the synthesis of coumarin derivatives under solvent-free conditions. Comptes Rendus Chimie 2013;16(5):407–11.
  48. Roomi AB, Widjaja G, Savitri D, Jalil AT, Mustafa YF, Thangavelu L, et al. SnO2:Au/Carbon Quantum Dots Nanocomposites: Synthesis, Characterization, and Antibacterial Activity. Journal of Nanostructures 2021;11(3):514–23.
  49. Augustine JK, Bombrun A, Ramappa B, Boodappa C. An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation. Tetrahedron Letters 2012;53(33):4422–5.
  50. Singh OM, Devi NS, Thokchom DS, Sharma GJ. Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities. European Journal of Medicinal Chemistry 2010;45(6):2250–7.
  51. Valizadeh H, Shockravi A. Synthetic Communications : An International Journal for Rapid Communication of Synthetic Organic Chemistry Task-Specific Ionic Liquid as Reagent and Reaction Medium for the One-Pot Horner – Wadsworth – Emmons – Type Reaction Under Microwave Irradiation. 2009;(May 2012):4341–9.
  52. Yavari I, Hekmat-Shoar R, Zonouzi A. A new and efficient route to 4-carboxymethylcoumarins mediated by vinyltriphenylphosphonium salt. Tetrahedron Letters 1998;39(16):2391–2.
  53. Ulgheri F, Marchetti M, Piccolo O. Enantioselective synthesis of (S)- and (R)-tolterodine by asymmetric hydrogenation of a coumarin derivative obtained by a Heck reaction. Journal of Organic Chemistry 2007;72(16):6056–9.
  54. Jumintono J, Alkubaisy S, Yánez Silva D, Singh K, Turki Jalil A, Mutia Syarifah S, et al. Effect of cystamine on sperm and antioxidant parameters of ram semen stored at 4 °C for 50 hours. Archives of Razi Institute 2021;76(4):981–9.
  55. M.Kadhim YAAOR. The role of amino acid functionalization for improvement of adsorption thioguanine anticancer drugs on the boron nitride nanotubes for drug delivery. Materials Chemistry and Physics 2022;287(2).
  56. Al-abdeen SHZ, Mustafa YF. Synthesis and Biological Potentials of Novel Benzodipyrone- Based Derivatives. Journal of Medicinal and Chemical Sciences 2022;5(6):1026–39.
  57. Sellès P, Mueller U. Expedient Synthesis of Highly Substituted Fused Heterocoumarins. Organic Letters 2004;6(2):277–9.
  58. Mustafa YF, Zain Al-Abdeen SH, Khalil RR, Mohammed ET. Novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused hybrids: Synthesis and biological activities. Results in Chemistry 2023;5:100942.
  59. Mustafa YF, Bashir MK, Oglah MK. Original and innovative advances in the synthetic schemes of coumarin-based derivatives: A review. Systematic Reviews in Pharmacy 2020;11(6):598–612.
  60. Aoki S, Amamoto C, Oyamada J, Kitamura T. A convenient synthesis of dihydrocoumarins from phenols and cinnamic acid derivatives. Tetrahedron 2005;61(39):9291–7.
  61. Jiang Y, Chen W, Lu W. Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes. Tetrahedron 2013;69(18):3669–76.
  62. Detsi A, Kontogiorgis C, Hadjipavlou-Litina D. Coumarin derivatives: an updated patent review (2015-2016). Expert Opinion on Therapeutic Patents 2017;27(11):1201–26.
  63. Jebir RM, Mustafa YF. Watermelon Allsweet: A promising natural source of bioactive products. Journal of Medicinal and Chemical Sciences 2022;5(5):652–66.
  64. Kasim SM, Abdulaziz NT, Mustafa YF. Synthesis and biomedical activities of coumarins derived from natural phenolic acids. Journal of Medicinal and Chemical Sciences 2022;5(4):546–60.
  65. Khalil RR, Mohammed ET, Mustafa YF. Various promising biological effects of Cranberry extract: A review. Clinical Schizophrenia and Related Psychoses 2021;15(S6):1–9.
  66. Khalil RR, Mohammed ET, Mustafa YF. Evaluation of in vitro antioxidant and antidiabetic properties of Cydonia Oblonga seeds’ extracts. Journal of Medicinal and Chemical Sciences 2022;5(6):1048–58.
  67. Mustafa YF, Kasim SM, Al-Dabbagh BM, Al-Shakarchi W. Synthesis, characterization and biological evaluation of new azo-coumarinic derivatives. Applied Nanoscience (Switzerland) 2023;13:1095–1102.
  68. Jasim SF, Mustafa YF. Synthesis, ADME Study, and antimicrobial evaluation of novel naphthalene-based derivatives. Journal of Medicinal and Chemical Sciences 2022;5(5):793–807.
  69. Mustafa YF, Al-omari NA. Design , Synthesis and Kinetic Study of Coumarin-Based Mutual Prodrug of 5-Fluorouracil and Dichloroacetic acid. Iraqi J Pharm Sci 2016;25(1):6–16.
  70. Sahoo SS, Shukla S, Nandy S, Sahoo HB. Synthesis of novel coumarin derivatives and its biological evaluations. European Journal of Experimental Biology 2012;2(4):899–908.
  71. Farahi M, Karami B, Tanuraghaj HM. Efficient synthesis of a new class of sulfonamide-substituted coumarins. Tetrahedron Letters 2015;56(14):1833–6.
  72. Waheed SA, Mustafa YF. Benzocoumarin backbone is a multifunctional and affordable scaffold with a vast scope of biological activities. Journal of Medicinal and Chemical Sciences 2022;5(5):703–21.
  73. Han L, Wu H, Cui Y, Zu X, Ye Q, Gao J. Synthesis and density functional theory study of novel coumarin-type dyes for dye sensitized solar cells. Journal of Photochemistry and Photobiology A: Chemistry 2014;290(1):54–62.
  74. Jaggavarapu SR, Kamalakaran AS, Nanubolu JB, Jalli VP, Gangisetty SK, Gaddamanugu G. Synthesis of novel benzopyrano[3,2-c]coumarins via tandem base promoted nucleophilic substitution and intramolecular electrophilic aromatic cyclization. Tetrahedron Letters 2014;55(27):3670–3.
  75. Jasim SF, Mustafa YF. A Review of Classical and Advanced Methodologies for Benzocoumarin Synthesis. Journal of Medicinal and Chemical Sciences 2022;5(5):676–94.
  76. El-Saghier AMM, Naili MB, Rammash BK, Saleh NA, Kreddan KM. Synthesis and antibacterial activity of some new fused chromenes. Arkivoc 2007;2007(16):83–91.
  77. Schlitzer M, Sattler I. Design , Synthesis , and Evaluation of Novel. 1999;1(13):2032–4.
  78. Ismael RN, Mustafa YF, Al-Qazaz HK. Citrullus lanatus, a Potential Source of Medicinal Products: A Review. Vol. 5, Journal of Medicinal and Chemical Sciences. 2022. p. 607–18.
  79. Mahesh M, Bheemaraju G, Manjunath G, Venkata Ramana P. Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide analogs as potential antibacterial and antifungal agents. Annales Pharmaceutiques Francaises 2016;74(1):34–44.
  80. Sharma M, Vyas VK, Bhatt S, Ghate MD. Therapeutic potential of 4-substituted coumarins: A conspectus. European Journal of Medicinal Chemistry Reports 2022;6(August):100086.
  81. Matos MJ, Vilar S, Gonzalez-Franco RM, Uriarte E, Santana L, Friedman C, et al. Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study. European Journal of Medicinal Chemistry 2013;63:151–61.
  82. Emmadi NR, Atmakur K, Bingi C, Godumagadda NR, Chityal GK, Nanubolu JB. Regioselective synthesis of 3-benzyl substituted pyrimidino chromen-2-ones and evaluation of anti-microbial and anti-biofilm activities. Bioorganic and Medicinal Chemistry Letters 2014;24(2):485–9.
  83. Paul K, Bindal S, Luxami V. Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity. Bioorganic and Medicinal Chemistry Letters 2013;23(12):3667–72.
  84. Mohammed ET, Khalil RR, Mustafa YF. Phytochemical Analysis and Antimicrobial Evaluation of Quince Seeds’ Extracts. Journal of Medicinal and Chemical Sciences 2022;5(6):968–79.
  85. Budzisz E, Brzezinska E, Krajewska U, Rozalski M. Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues. European Journal of Medicinal Chemistry 2003;38(6):597–603.
  86. Jasim SF, Mustafa YF. Synthesis and antidiabetic assessment of new coumarin- disubstituted benzene conjugates: An in silico-in virto study. Journal of Medicinal and Chemical Sciences 2022;5(6):887–99.
  87. Khode S, Maddi V, Aragade P, Palkar M, Ronad PK, Mamledesai S, et al. Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. European journal of medicinal chemistry 2009;44(4):1682–8.
  88. Annunziata F, Pinna C, Dallavalle S, Tamborini L, Pinto A. An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities. International Journal of Molecular Sciences 2020;21(13):1–83.
  89. Waheed SA, Mustafaa YF. Novel naphthalene-derived coumarin composites: synthesis, antibacterial, and antifungal activity assessments. Eurasian Chemical Communications 2022;4(8):709–24.
  90. Márquez N, Sancho R, Bedoya LM, Alcamí J, López-Pérez JL, San Feliciano A, et al. Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-κB pathway. Antiviral Research 2005;66(2–3):137–45.
  91. Jebir RM, Mustafa YF. Novel coumarins isolated from the seeds of Citrullus lanatus as potential antimicrobial agents. Eurasian Chemical Communications 2022;4(8):692–708.
  92. Pingaew R, Saekee A, Mandi P, Nantasenamat C, Prachayasittikul S, Ruchirawat S, et al. Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents. European Journal of Medicinal Chemistry 2014;85:65–76.
  93. Aggarwal R, Kumar S, Kaushik P, Kaushik D, Gupta GK. Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5- trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles. European Journal of Medicinal Chemistry 2013;62:508–14.
  94. Jasim SF, Mustafa YF. New fused-coumarin composites: Synthesis, anticancer and antioxidant potentials evaluation. Eurasian Chemical Communications 2022;4(7):607–19.
  95. Basanagouda M, Jambagi VB, Barigidad NN, Laxmeshwar SS, Devaru V, Narayanachar. Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl- coumarins as potential anti-cancer and anti-mycobacterial agents. European Journal of Medicinal Chemistry 2014;74:225–33.
  96. Sashidhara K V., Rao KB, Singh S, Modukuri RK, Aruna Teja G, Chandasana H, et al. Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents. Bioorganic and Medicinal Chemistry Letters 2014;24(20):4876–80.
  97. Waheed SA, Mustafa YF. Synthesis and evaluation of new coumarins as antitumor and antioxidant applicants. Journal of Medicinal and Chemical Sciences 2022;5(5):808–19.
  98. Al-hatim RR, Al-alnabi DIB, Al-younis ZK, Al-shawi SG, Singh K, Abdelbasset WK, et al. Extraction of tea polyphenols based on orthogonal test method and its application in food preservation. Food Science and Technology 2022;42:e70321.
  99. Jebir RM, Mustafa YF. Natural products catalog of allsweet watermelon seeds and evaluation of their novel coumarins as antimicrobial candidates. Journal of Medicinal and Chemical Sciences 2022;5(5):831–47.
  100. Melagraki G, Afantitis A, Igglessi-Markopoulou O, Detsi A, Koufaki M, Kontogiorgis C, et al. Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts. European Journal of Medicinal Chemistry 2009;44(7):3020–6.
  101. Patel RB, Chikhalia KH, Pannecouque C, Clercq E De. Derivatives and their Antibacterial and Anti-HIV Studies. 2007;18(2):312–21.
  102. Waheed SA, Mustafa YF. The in vitro effects of new albocarbon-based coumarins on blood glucose-controlling enzymes. Journal of Medicinal and Chemical Sciences 2022;5(6):954–67.
  103. Hammoodi SH, Ismael SS, Mustafa YF. Mutual prodrugs for colon targeting: A review. Eurasian Chemical Communications 2022;4(12):1251–65.
  104. Patil SB. Medicinal significance of novel coumarin analogs: Recent studies.  Results in Chemistry 2022;4:100313.