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Thionyl Chloride: A Catalyst of Synthetic Chemical Interest

Document Type : Review Paper

Authors

1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

2 Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq

10.33899/iphr.2023.142271.1053

Abstract

Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed papers. Aim: The literature that has been released since the previous assessment in 1980, which mainly focused on the responses of active methylene compounds, is where this review places its focus. In the present overview, we also discuss O- and N-nucleophiles. For the most part, patents have been disregarded in this analysis in order to keep it feasible. Conclusion: The authors concluded that SOCl2 has a variety of behaviors, including the ability to function as an initiator or a reactant, which makes it essential for the synthesis of many chemically reactive intermediates and final products. Additionally, SOCl2 can speed up and reduce the duration of traditionally long reactions, thereby raising its importance.

Keywords

Main Subjects

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Iraqi Journal of Pharmacy

Articles in Press, Accepted Manuscript
Available Online from 28 August 2023
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  • Receive Date: 01 August 2023
  • Revise Date: 23 August 2023
  • Accept Date: 28 August 2023
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