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The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study

Document Type : Review Paper

Authors

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

10.33899/iphr.2023.142073.1051

Abstract

Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays an important role in their medical action. Synthetic dioxolane conjugates have been studied in a variety of biological fields, including cytotoxicity, antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory activity, and have demonstrated a distinct potency that encourages further research in this mode. Aim: This review highlights the most recent studies on dioxolane ring conjugates in various biological fields as a promising bioactive heterocyclic scaffold. Conclusion: The hydrogen bonding of the oxygen atoms in this heterocyclic ring with the target site may be responsible for the enhanced ligand-target interactions and improved bioactivity.

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Iraqi Journal of Pharmacy

Articles in Press, Accepted Manuscript
Available Online from 22 August 2023
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  • Receive Date: 28 July 2023
  • Revise Date: 17 August 2023
  • Accept Date: 22 August 2023
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