Sonographic Assessment of Submandibular Salivary Glands in Hypothyroid Rat’s Pups Before and After Ashwagandha Root Extract Treatment

Alhalawachee, Zahraa; Taqa, Ghada Abd Alrhman Abd Alrhman

doi:10.33899/iphr.2023.137764.1021

Document Type : Research Paper

Authors

¹ Ministry of Health, Nineveh Health Directorate, Mosul, Iraq

² Department of Dental Basic Sciences, College of Dentistry. University of Mosul, Mosul, Iraq

https://doi.org/10.33899/iphr.2023.137764.1021

Abstract

Background: One of the most common chronic diseases globally is hypothyroidism. Thyroid hormones serve a significant role in maintaining the proper function and shape of the salivary gland. The aim of the study: Investigate the function of Ashwagandha roots extract in providing a protection role for salivary glands in hypothyroid rats following postnatal exposure to Propylthiouracil. Materials and Methods: Ten pregnant albino rats were obtained. Until the rat pups were detected, each pregnant rat was kept individually in clean rodent plastic. At postnatal day 3 (PND3), forty male rats were randomly assigned to one of two groups: group A, which served as a control group, and group B, which received orally (1mg/kg) Propylthiouracil (PTU) for three weeks. At PND22, group B was divided up into three subgroups: B1, the hypothyroid group that got no therapy; B2, the hypothyroid group that received an aqueous extract of Ashwagandha roots (200 mg/kg) for 21 days; and B3, the hypothyroid group that received Levothyroxine (4g/100g/day) for 21 days. At the end of the trial, the submandibular gland was assessed using sonographic instruments in all groups. Results: the sonographic assessment of hypothyroid group’s submandibular gland showed an increase in the overall size of the gland, a heterogeneous gland with a honeycomb appearance and hypoechoic regions in group remains without treatment, while the results in hypothyroid pups fed with Ashwagandha roots extract indicated a small improvement in gland size and echotexture when compared to pups who received levothyroxine, owing to its antioxidant properties.

Keywords

Main Subjects

Pharmacology and Toxicology

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Iraqi Journal of Pharmacy

Sonographic Assessment of Submandibular Salivary Glands in Hypothyroid Rat’s Pups Before and After Ashwagandha Root Extract Treatment

References

References

Volume 20, Issue 1
June 2023
Page 1-6

Sonographic Assessment of Submandibular Salivary Glands in Hypothyroid Rat’s Pups Before and After Ashwagandha Root Extract Treatment

References

References

Volume 20, Issue 1June 2023Page 1-6

Volume 20, Issue 1
June 2023
Page 1-6