Iraqi Journal of Pharmacy

Abstract

Background: Mean platelet volume is an important marker that shows the activation and function of the platelet which is effective in the inflammatory process.
Aim of the study: To show the relationship between mean platelet volume and disease activity score in psoriatic arthritis patients (PsA).
Methods: a cross-sectional study was done. A total of 90 patients participated in the study. The sample was collected over 6 months. Mean platelet volume was measured and correlated with disease activity score, and the relation between mean platelet volume with other disease activity markers like erythrocyte sedimentation rate (ESR) and C-reactive proteins (CRP)was determined. The serum of (cholesterol, tri-glycerides, low density lipoproteins, and high density lipoproteins) were estimated and correlated with DAPSA scores.
Results: The mean (SD) of MPV was 10.4fl .It is evident in Psoriatic arthritis patients that around two thirds (64.9%) of patients were with high MPV and 39.4% of patients were with normal MPV. There is statistically significant positive correlation between the MPV and the DAPSA score, and the positive significant correlation between disease activity score with ESR, and CRP.  Also, there was a positive correlation between s. cholesterol, s. triglyceride, LDL and DAPSA score while a negative significant correlation was found between DAPSA score and HDL.
Conclusion: Higher disease activity in PsA patients is associated with correspondingly high MPV and high level of inflammatory markers like ESR and CRP, and lipid profiles.