Document Type : Review Paper


Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.


Objective: This brief review highlights the recent advances in the synthesis of coumarin-based derivatives from phenols, aldehydes, ketones, and various other functional group-containing starting compounds. Also, the recent developments in the conditions of several original synthetic methods involving Pechmann and Knoevenagel reactions are being revised.
Conclusion: It is critical to decreasing energy consumption, prevent hazardous chemicals, and get pure molecules in high yields during synthesis. Scientists working in this sector will be able to utilize this comparison of reaction conditions and compound yields to create new efficient procedures.