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Iraqi Journal of Pharmacy

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High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater

    Nief Rahman Ahmed

Iraqi Journal of Pharmacy, 2014, Volume 14, Issue 1, Pages 87-94
10.33899/iphr.2019.161198

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Abstract

Objective: A reverse phase high performance liquid chromatographic method (RP-HPLC) has been developed for the determination of  tadalafil in the pharmaceutical formulations  and environmental wastewater samples.
Method: Different analytical columns with various  stationary phases were tested. Good separation was achieved using supelcoC18 column (25cm x 4.6 mm. 5 µm) . The mobile phase (methanol: water: Triethylamine) , pH adjusted to 4.0 with dilute phosphoric acid was pumped at a flow rate of 1.3 ml/min in the ratio of 60:38:2   and the peaks  were detected at 220 nm.
Results: Linearity was obtained in the concentration range of 0.0 4-0.28 mg/ml .The RSD was found to be less than 1% indicating the method is precise and the recovery was100±1.25% indicating the method is accurate
 Conclusion: The proposed HPLC method may be used for determining tadalafil in pure drug samples , pharmaceutical dosage forms and environmental wastewater samples.
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(2019). High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater. Iraqi Journal of Pharmacy, 14(1), 87-94. doi: 10.33899/iphr.2019.161198
Nief Rahman Ahmed. "High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater". Iraqi Journal of Pharmacy, 14, 1, 2019, 87-94. doi: 10.33899/iphr.2019.161198
(2019). 'High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater', Iraqi Journal of Pharmacy, 14(1), pp. 87-94. doi: 10.33899/iphr.2019.161198
High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater. Iraqi Journal of Pharmacy, 2019; 14(1): 87-94. doi: 10.33899/iphr.2019.161198
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