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Iraqi Journal of Pharmacy

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Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b

    Farah Waleed Mahmood Shamil Hashim Othman

Iraqi Journal of Pharmacy, 2014, Volume 14, Issue 1, Pages 23-31
10.33899/iphr.2019.161191

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Abstract

Objective: To investigate the effect of Atorvastatin vs. placebo on some inflammatory markers in patients with multiple sclerosis treated by interferone beta-1b.To achieve the aim of this study, a randomized control comparative trial was adopted.
Patients and Methods: A total of 100 patients with multiple sclerosis were recruited and investigated for some inflammatory markers which included, interleukin-2, tumor necrosis factor-α, C-reactive protein, and erythrocyte sedimentation rate. The patients were divided into 2 groups, namely the atorvastatin group which consisted of 50 patients and the placebo group which consisted of 50 patients. The patient groups were followed- up for 12 weeks during which the above parameters were measured before starting therapies and at the end of the follow-up period using commercially available kits. The patient groups were compared with the control group consisted of 50 apparently healthy subjects.
Results: The IL-2,TNF-α,CRP and ESR at baseline in both patient groups were found significantly elevated as compared with the control group ( p< 0.001) . The use of atorvastatinhas resulted in significant decrease on the above parameters with non-significant effects in the placebogroup. Atorvastatinappeared to be superior in compared with the placebo group.
Conclusion: The use of atorvastatinfor 12 weeks in patients withmultiple sclerosis treated by interferone-beta has beneficial effect on some inflammatory markers studied in this research( IL-2,TNF-α,CRP and ESR).
Keywords:
    Multiple Sclerosis Atorvastatin Interferone-beta-1b
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(2019). Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b. Iraqi Journal of Pharmacy, 14(1), 23-31. doi: 10.33899/iphr.2019.161191
Farah Waleed Mahmood; Shamil Hashim Othman. "Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b". Iraqi Journal of Pharmacy, 14, 1, 2019, 23-31. doi: 10.33899/iphr.2019.161191
(2019). 'Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b', Iraqi Journal of Pharmacy, 14(1), pp. 23-31. doi: 10.33899/iphr.2019.161191
Effects of atorvastatin on some inflammatory markers in patients with multiple sclerosis treated by interferon beta-1b. Iraqi Journal of Pharmacy, 2019; 14(1): 23-31. doi: 10.33899/iphr.2019.161191
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