Pharmaceutical Chemistry
The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study

Moath Kahtan Bashir; Mahmood Khudhayer Oglah; Yasser Fakri Mustafa; Ahmed Abdul-jabbar Mahmood

Volume 20, Issue 2 , December 2023, , Page 99-110

https://doi.org/10.33899/iphr.2023.142073.1051

Abstract
  Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays ...  Read More ...

Pharmaceutical Chemistry
Thionyl Chloride: A Catalyst of Synthetic Chemical Interest

Noor Ahmed Waheed; Noora Thamer Abdulaziz; Sawsan Hasan Hammodi; Yasser Fakri Mustafa

Volume 20, Issue 2 , December 2023, , Page 111-125

https://doi.org/10.33899/iphr.2023.142271.1053

Abstract
  Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed ...  Read More ...

Pharmaceutical Chemistry
Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes

Rana Naeem Jibroo; Yasser Fakri Mustafa; Wejdan Al-Shakarchi

Volume 20, Issue 2 , December 2023, , Page 133-151

https://doi.org/10.33899/iphr.2023.142709.1054

Abstract
  Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which ...  Read More ...

Pharmaceutical Chemistry
Synthesis and Pharmacological Profiles of 6,7-Dihydroxycoumarin and Its Derivatives: A Concise Review

Nameer Mazin Zeki; Yasser Fakri Mustafa

Volume 20, Supplementary Issue 1 , December 2023, , Page 174-188

https://doi.org/10.33899/iphr.2023.143017.1059

Abstract
  Background: Esculetin, scientifically referred to as 6,7-dihydroxycoumarin, functions as the primary bioactive constituent found in Cortex Fraxini (commonly known as ash bark), an ancient Asian medicinal substance. Herbal practitioners utilize the outer layer of the branch or stem bark of Cortex Fraxini ...  Read More ...

Pharmaceutical Chemistry
Thermosonication-Catalyzed Synthesis of New 3-Esterified Coumarins as Biocompatible Antitumor Candidates

Sawsan Hasan Hammodi

Volume 20, Supplementary Issue 1 , December 2023, , Page 236-242

https://doi.org/10.33899/iphr.2023.144182.1066

Abstract
  Background: Coumarin chemical moiety and its-based molecules attracted a lot of research attention by chemists of natural products and organic synthesis. This attention works in two directions: synthetic approaches and biological activities. Methods: In this work, salicylaldehyde was condensed via a ...  Read More ...

Pharmaceutical Chemistry
A Narrative Review of Benzo-Fused Coumarins, Shedding Light on Their Medicinal Activities

Yasser Fakri Mustafa; Sarah Ahmed Waheed; Sara Firas Jasim; Rahma Mowaffaq Jebir; Reem Nadher Ismael; Omar Qutachi

Volume 20, Issue 1 , June 2023, , Page 7-16

https://doi.org/10.33899/iphr.2023.138286.1024

Abstract
  Background: Coumarins and their derivatives excel in chemical diversity, coupled with a wide variety of biological potentials, and tend to be beneficial to the health of the human body. One of these derivatives that has sparked the attention of medicinal chemistry specialists in recent decades is benzo-fused ...  Read More ...

Pharmaceutical Chemistry
Docking Study for New 7-Aminocephalosporinic Acid Derivatives as Potential Inhibitors for β-Lactamases

Ahmed A. Saleh; Ahmed A. J. Mahmood

Volume 20, Issue 1 , June 2023, , Page 23-32

https://doi.org/10.33899/iphr.2023.138503.1025

Abstract
  Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections. Though their resistance can quickly spread on a universal scale, bacterial resistance is primarily caused by the production of β-lactamases. ...  Read More ...