Keywords : hyperplasia

Histological and Histochemical Changes Induced by Human Chorionic Gonadotropin on Prostate of Adult albino Rats

Waleed H. Kasim; Maha A. Al-Sammak

Iraqi Journal of Pharmacy, 2018, Volume 15, Issue 1, Pages 12-21
DOI: 10.33899/iphr.2018.164167

Aims of the study: To evaluate the histological and histochemical changes induced by human chorionic gonadotropin (hCG) on the adult prostate and to correlate the changes with the levels of testosterone.
Materials and Methods: eighty adult male albino rats were divided into 4 groups; 3 treated and 1 control. The treated groups were received 10, 50 or 100 IU/kg BW of hCG, while the controls received normal saline. The doses were given twice weekly for 3 months via subcutaneous injections. Subsequently, on day 1, 30, 60 and 90 post therapy, blood samples and the prostate glands were obtained for evaluation.
Results: All the doses of hCG caused accumulation of secretory products within the prostate, which resulted in dilatation of the acinar lumens, reduction of the mucosal folds, and non dose dependent diminution in height of the lining epithelial cells. Moreover, foci of hyperplasic cells were observed in the prostate. The therapy increased the collagen fibers of the gland. The general distribution of the Periodic Acid-Sciff (PAS) +ve material was not altered. Most of these changes were reversible within 3 months.
Conclusions: Treatment with hCG causes accumulation of secretory products within the prostate and in turn affects the structure of the prostate.