Keywords : Glycemic control

A review of the effect of Coenzyme Q10 in patients with polycystic ovary syndrome

Shahad A. Badr; Zeina A. Althanoon

Iraqi Journal of Pharmacy, 2021, Volume 18, Issue 1, Pages 108-117
DOI: 10.33899/iphr.2021.168805

Background: Women with polycystic ovary syndrome are usually suffering from many metabolic disturbances as insulin resistance, so the use of Co enzyme Q10 in those patients improve metabolic changes and insulin resistance resulting in better ovulation.
Mitochondrial dysfunction in the eggs is related to reduction in the oxidative phosphorylation which leads to lower ATP production by mitochondria, also results in deprived reproductive performance, including poor oocyte quality, lessened ovarian store, abnormal conception and unbalanced embryo development.
Objective: The aim of this review is to observe the effects of co enzyme Q10 in PCOS patients by emphasizing many studies that showing the effect of CoQ10 on the metabolic parameters such as (Fasting serum glucose, HbA1c%, total cholesterol, LDL, HDL and triglyceride level).
This article suggested that CoQ10 therapy possess beneficial effect in improving the clinical parameters of PCOS patients including HbA1c%, fasting serum glucose and lipid profile parameters.

The Relationship Between Magnesium Supplementation and Glycemic Control in Diabetic Patients: A Review

Doaa K. Ibrahim; Zeina A. Al-Thanoon

Iraqi Journal of Pharmacy, 2021, Volume 18, Issue 1, Pages 57-66
DOI: 10.33899/iphr.2021.168801

Background: Diabetes mellitus is a chronic disease with increasing worldwide prevalence. There are many studies to observe the role of minerals on the glycemic state in diabetic patients. One of the in the human se minerals is magnesium. Magnesium is the fourth most abundant mineral in the human body. It has a role in the action of more than 300 enzymes most of them is ATP-dependent reactions. Finally, magnesium has an effect on glucose metabolism, lipid metabolism, nucleic acid synthesis, and energy production. The relationship between magnesium and DM is complex and multifactorial. There is an association between hypomagnesemia and insulin resistance by affecting phosphorylation of insulin receptors, insulin signaling and insulin action. Another consequence of hypomagnesemia is oxidative stress which is also present in the pathogenesis of DM. Objective: This work is trying to emphasize the important role of magnesium in the control of the glycemic state in diabetic patients through highlighting the studies conducted to correlate between magnesium level in the body, dietary magnesium intake, or magnesium supplementation with risk of diabetes mellitus occurrence, insulin sensitivity or glycemic control in diabetic patients. This article suggested that magnesium therapy may be beneficial in improving the clinical parameters of diabetic patients including HbA1c%, fasting serum glucose, and fasting insulin level.