Official Journal of the College of Pharmacy, University of Mosul
Pharmaceutical Chemistry
The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study

Moath Kahtan Bashir; Mahmood Khudhayer Oglah; Yasser Fakri Mustafa; Ahmed Abdul-jabbar Mahmood

Volume 20, Issue 2 , December 2023, , Page 99-110

  Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays ...  Read More ...

Pharmaceutical Chemistry
Thionyl Chloride: A Catalyst of Synthetic Chemical Interest

Noor Ahmed Waheed; Noora Thamer Abdulaziz; Sawsan Hasan Hammodi; Yasser Fakri Mustafa

Volume 20, Issue 2 , December 2023, , Page 111-125

  Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed ...  Read More ...

Pharmaceutical Chemistry
Coumarin-Based Derivatives: A Review of Their Synthetic Routes, Reactivity, and Biomedical Attributes

Rana Naeem Jibroo; Yasser Fakri Mustafa; Wejdan Al-Shakarchi

Volume 20, Issue 2 , December 2023, , Page 133-151

  Background: Coumarin-based derivatives (Cou-Ds) are one of the most important types of heterocycles, with a wide range of uses in synthetic and medicinal chemistry. Cou-Ds have interested researchers due to their wide range of biomedical potential and application as valuable synthetic scaffolds, which ...  Read More ...

Pharmacognosy & Natural Products
Bell Pepper Biowaste Products as Medicinally Valuable Nutraceuticals: A Comprehensive Review

Areej Hazem Alyamoor; Yasser Fakri Mustafa

Volume 20, Issue 2 , December 2023, , Page 152-167

  Background: The numerous additional valued substances present within plant biowaste products have a wide range of candidates regarding their recycling, promoting the idea of the circular economy. The bell pepper (BP, Capsicum annum L.) has high concentrations of various vitamins and minerals. Also, the ...  Read More ...

Pharmaceutical Chemistry
Synthesis and Pharmacological Profiles of 6,7-Dihydroxycoumarin and Its Derivatives: A Concise Review

Nameer Mazin Zeki; Yasser Fakri Mustafa

Volume 20, Supplementary Issue 1 , December 2023, , Page 174-188

  Background: Esculetin, scientifically referred to as 6,7-dihydroxycoumarin, functions as the primary bioactive constituent found in Cortex Fraxini (commonly known as ash bark), an ancient Asian medicinal substance. Herbal practitioners utilize the outer layer of the branch or stem bark of Cortex Fraxini ...  Read More ...

Pharmaceutical Chemistry
A Narrative Review of Benzo-Fused Coumarins, Shedding Light on Their Medicinal Activities

Yasser Fakri Mustafa; Sarah Ahmed Waheed; Sara Firas Jasim; Rahma Mowaffaq Jebir; Reem Nadher Ismael; Omar Qutachi

Volume 20, Issue 1 , June 2023, , Page 7-16

  Background: Coumarins and their derivatives excel in chemical diversity, coupled with a wide variety of biological potentials, and tend to be beneficial to the health of the human body. One of these derivatives that has sparked the attention of medicinal chemistry specialists in recent decades is benzo-fused ...  Read More ...

A review on coumarin backbone: An attractive scaffold for promising bioactive compounds

Sara F. Jasim; Yasser F. Mustafa

Volume 18, Issue 2 , December 2021, , Page 104-125

  Background: Coumarin moiety is found in many naturally occurring products that have been used for many decades in traditional medicine around the world. Coumarin has distinctive physicochemical properties and can be easily transformed into a wide range of functionalized coumarins. As a result, a large ...  Read More ...

Synthesis of coumarin-based derivatives from different starting materials: A review of ongoing developments

Sarah A. Waheed; Yasser F. Mustafa

Volume 18, Issue 2 , December 2021, , Page 126-138

  Objective: This brief review highlights the recent advances in the synthesis of coumarin-based derivatives from phenols, aldehydes, ketones, and various other functional group-containing starting compounds. Also, the recent developments in the conditions of several original synthetic methods involving ...  Read More ...

Natural Coumarin-Lead Compounds: A Review of Their Medicinal Potentials

Rahma M. Jebir; Yasser F. Mustafa

Volume 18, Issue 2 , December 2021, , Page 139-161

  Background: Natural coumarins group, a principal member of the benzopyrone family, is one of the naturally occurring substances obtained ordinarily from plant origins, with antibacterial, anticoagulant, antihypertensive, anticancer, antioxidant, anti-inflammatory, and many other medicinal potentials. ...  Read More ...

Coumarin-based products: Their biodiversity and pharmacology

Reem N. Ismael; Yasser F. Mustafa; Harith K. Al-Qazaz

Volume 18, Issue 2 , December 2021, , Page 162-179

  Background: The plant kingdom generates and releases a wide range of secondary-metabolites, which have several effects on biological, toxicological, and ecological systems that may act in a similar manner to chemically synthesized compounds. One of these secondary-metabolites are coumarins, which are ...  Read More ...

A review on the antibacterial potential of cantabiline-based derivatives

Noora T. Abdulaziz; Yasser F. Mustafa

Volume 17, Issue 1 , January 2020, , Page 93-114

  Objective: The target of this review study is to highlight the importance of cantabiline and its derived compound as antibacterial agents. Also, to take into consideration the characteristic structural features that can enhance the capability of these compounds to fight pathogenic bacteria.Methods: The ...  Read More ...