Rasha Dhahir; Myasar Al-Kotaji
Abstract
Background: Orally disintegrating tablets (ODTs) have gained an increasing interest in the pharmaceutical industry for the last years. Several technologies have been sophisticated for ODTs to improve patient compliance. In the present work, an attempt has been made to formulate and evaluate cinnarizine, ...
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Background: Orally disintegrating tablets (ODTs) have gained an increasing interest in the pharmaceutical industry for the last years. Several technologies have been sophisticated for ODTs to improve patient compliance. In the present work, an attempt has been made to formulate and evaluate cinnarizine, a drug for motion sickness, in an easy to administer, rapid disintegrated dosage form (oral lyophilizates with enhanced disintegration and dissolution profile and consequent potential improvement in bioavailability.Materials and Methods: Cinnarizine oral lyophilizates were prepared by dispersing the drug in an aqueous solution of mannitol, hydroxypropyl methyl cellulose, and glycine. Different formulations were prepared by freeze-drying (lyophilisation) technique. The effect of concentration of mannitol, hydroxypropyl methyl cellulose, and freezing time on the lyophilizates characteristics was investigated. The drug-excipient interaction was investigated as well.Results: The resulting cinnarizine oral lyophilizates showed an enhanced disintegration (27.5±3.53 sec to 56±12.73 sec) and enhanced dissolution profile (25.09% to 44.7% after two minutes). The infrared spectroscopic studies showed no drug-excipient interactions. Furthermore, increasing the concentration of mannitol, increasing the concentration of hydroxypropyl methyl cellulose and duplication of the duration of freezing time had a negative influence on the disintegration and dissolution properties of the resulting lyophilizates.Conclusion: Cinnarizine oral lyophilizates were successfully prepared and resulted in a rapid disintegration, high dissolution profile, with stable characteristics and without noticeable drug-excipient interaction.
Amina M. Al-Nima; Zahraa S. Qasim; Myasar Al-Kotaji
Abstract
Objectives: This work aims at formulating licorice as topical gel preparation and at exploring its antimicrobial efficacy against different types of microorganisms including two types of bacteria Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aerueginosa) and one type of yeast, Candida albicans ...
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Objectives: This work aims at formulating licorice as topical gel preparation and at exploring its antimicrobial efficacy against different types of microorganisms including two types of bacteria Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aerueginosa) and one type of yeast, Candida albicans (C.albicans).Materials and Method: Different gel formulas were prepared using two different types of gelling agent Carbopol 934 and HPMC (methocel E5) with different extract concentrations. All the prepared formulas were physically and chemically characterized, and the selected formula showed good appearance and consistency, spreadability, accepted pH and physiologically compatible to the skin. The selected formula was further characterized by studying the in-vitro antimicrobial activity.Result and Discussion : Results showed that licorice gel can be formulated successfully using Carbopol 934 as gelling agent and the selected formula exhibited good antimicrobial activity against (S.aureus) and (C.albicans), but it showed no antimicrobial activity against (P.aerueginosa). Consequently, the prepared topical gel of licorice could be considered as an efficient alternative to the common topical antimicrobial agents. Furthermore, the results pointed out that the prepared licorice gel has good stability at room temperature with no significant difference (p≤0.05) after storing for four months.Conclusion: In this work a suitable candidate of new herbal antimicrobial topical gel formulation was proposed to enter into the market.