Synthesis of ketoprofen - L- phenylalanine and Ketoprofen -y- Aminobutyric acid ethyl esters as possible prodrugs

Muthanna D.Saud; Fuad H. Al-Jawad; Adheed K. Sharrad

Volume 6, Issue 1 , December 2006, , Page 20-24

https://doi.org/10.33899/iphr.2006.50550

Abstract
  Ethyl ester HCI of the amino acids -L- phenylalanine and 7- Aminobutyric acid were synthesized through reaction of these amino acids with thionyl chloride in absolute ethanol. The amino group of these esters were allowd to react with the carboxylic acid functionality of ketoprofen (NSAID) using dicyclohexylcarbodiimide ...  Read More ...