In vitro kinetic study of donepezil N- oxide metabolites

Faris T. Abachi; Ammar B. Behnan; Riyath A. Atto

Volume 11, Issue 2 , December 2011, , Page 93-101

https://doi.org/10.33899/iphr.2011.49912

Abstract
  Objective: The aim of this study was to examine the metabolism of donepezil via N – oxidation of donepezil HCl in vitro, and the kinetic studies at a temperature similar to that of the human body. Methods: Direct reaction of donepezil with hydrogen peroxide and formic acid at room temperature, ...  Read More ...